How Universal Probabilistic Programming Languages Democratize Modeling in Computational Biology

School of Mathematical and Statistical Sciences

14th Annual Research Day

10 April 2024

Viktor Senderov

vsenderov.github.io/2024-galway-slides

1st Paradigm

Experimental science

4th Paradigm

Data-driven science

2nd Paradigm

Theoretical science

3th Paradigm

Computational science

Evolution of scientific paradigms

modified from Jim Gray (2007)

Informatics challenges

Data ingestion
Managing big data
Ontology and Sharing
Query and Visualization
integrating data and literature
 

Experiments

Literature

Simulations

Observations

facts

Questions

Answers

Computational challenges

Building and executing models

Documenting experiments

modified from Jim Gray (2007)

Data-driven science

facts

facts

facts

Idea (thought)

Description (language)

Formalization (math) - What?

Algorithm (source) - How?

Program (executable)

 

Idea (thought)

Description (language) 

Formalization (math) - What?

Algorithm (source) - How?

Program (executable)

 

Idea (thought)

Description (language) 

Formalization (PPL) - What?

Algorithm (auto) - How?

Program (executable)

 

Probabilistic Programming Languages

Bayesian modeling with ppls

Probabilistic programming languages (PPL) are domain specific languages (DSL) with the objective of facilitating Bayesian analysis.

The Bayesian model is represented as a conditional simulation in the form of a probabilistic program.

A compiler then operates on the probabilistic program:

  • static analysis (by examining the program structure without running it)
  • statistical inference (by running the program within an inference procedure) - model comparison, sampling, learning parameters

Given an abstract problem, e.g. parameter estimation of a Bayesian model.

Difference between programming and probabilistic programming?

Solution - e.g. MCMC sampling of the posterior parameters - encoded by the programmer.

Problem - a programmatic representation of the Bayesian model as a conditional simulation - encoded by the programmer.

Solution - e.g. MCMC sampling of the posterior parameters -supplied automatically by the compiler.

\overbrace{p(\theta | x)}^{\scriptsize{\text{posterior distribution}}} = \frac{ \overbrace{p(x | \theta)}^{\scriptsize{\text{likelihood}}} \overbrace{p(\theta)}^{\scriptsize{\text{\: prior}}} } { \underbrace{p(x)}_{\scriptsize{\text{normalizing constant}}} }

observe

assume

HISTORY of ppls

IN biology

  • RevBayes: a probabilistic graphical model
  • BUGS (Bayesian inference Using Gibbs Sampling)
  • WinBUGS
  • JAGS (Just Another Gibbs Sampler)
  • Stan: including Hamiltonian Monte Carlo (HMC)
  • PyMC:  utilizes TensorFlow (for its successor, PyMC4) for automatic differentiation and GPU acceleration, MCMC-based.
  • Church: a Lisp-like PPL, emphasizing expressiveness and the ability to define recursive stochastic functions.
  • Infer.NET: supports a variety of message passing algorithms for probabilistic inference.
  • WebPPL: A more recent addition, WebPPL is a lightweight PPL that runs in web browsers.
  • Edward (and Edward2): integrates with TensorFlow
  • Turing.jl: A PPL for the Julia programming language

miking and treeppl

  • Miking: a platform for meta-programming, i.e. a language to create DSLs

Download and installation: https://github.com/treeppl/treeppl

📰 Senderov et al. "TreePPL: A Universal Probabilistic Programming Language for Phylogenetics." 2023 doi: https://doi.org/10.1101/2023.10.10.561673

  • TreePPL: a DSL built on top of the Miking platform
    • universal: stochastic recursion and stochastic branching
    • easy syntax
    • static types (with type inference)
    • compiled
    • supports different inference schemas

... and supply the data and the data manipulation functions

Statistical Inference​

  • importance sampling
  • Various sequential Monte Carlo schemas
    • bootstrap particle filter (BPF) and the alive particle filter (APF)
  • Various Markov-chain Monte Carlo schemas
    • lightweight MCMC, trace MCMC, naive MCMC
  • hybrid schema: particle MCMC–particle independent Metropolis-Hastings (PMCMC-PIMH)

You model, e.g. a regression model, expressed as a conditional simulation (not inference!)...

Statistical Inference​

  • importance sampling
  • Various sequential Monte Carlo schemas
    • bootstrap particle filter (BPF) and the alive particle filter (APF)
  • Various Markov-chain Monte Carlo schemas
    • lightweight MCMC, trace MCMC, naive MCMC
  • hybrid schema: particle MCMC–particle independent Metropolis-Hastings (PMCMC-PIMH)

Example: Polynomial regression

model function poly(data: Real[][]): Int {
    assume n ~ Poisson(1.0); // sample the degree of the polynomial

    // Sample the coefficients from n + 1 (we need one coeff for const poly)
    let coeffs = repApply(addi(n, 1), function() {
        assume g ~ Gaussian(0.0, 1.0);
        return g;
    });

    // likelihood
    let sigma = 1.0; // noise term
    sapply(data, function(datum: Real[]) {
        let predictedY = polynomialFunction(coeffs, datum[1]);
        observe datum[2] ~ Gaussian(predictedY, sigma);
    });
    
    return n;
}

TreePPL source code for the polynomial regression:

Not shown: a function polynomialFunction that evaluates a polynomial as specified by a coefficient vector at a given data point.

TreePPL

Model

Statistical Inference

TreePPL

Model

Statistical Inference

Sequential Monte Carlo Inference

SMC Algorithm

SMC = Importance Sampling + Resampling

  1. Sample particles \(x_t\sim p(x_t|x_{t-1})\)
  2. Propagate particles until checkpoint \(y_t\)
  3. Resample particles based on particle likelihood \(p(y_t|x_t)\) and advance \(t\)

Hidden Markov Model

Animation re-used with author's permission from: https://github.com/dlunde/smc-example

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

LOCALIZATION model

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

SMc AIRCRAFT LOCALIZATION

Advantages of smc

  • Online inference
  • Model comparison via Bayes factors
  • Embarrassingly parallelizable

PPLs in MAcroevolution

ClaDS               

CRBD               

macroevolutionary diversification models

TDBD

AnaDS/BDD

  • Lineage-specific and time-dependent models tend to be a better fit for most bird clades
  • Trait evolution, not speciation, drives gradual diversification rate changes in birds

Path degeneracy

Illustration of path degeneracy

https://awllee.github.io/smc-tutorial/smc-tutorial.html#36

PPL Implementation

Delayed Sampling

  • A variance-minimization technique
  • You don't need to sample all r.v.'s in a model

Let \(k \in \mathbb{N}\) in

$$\nu \sim Gamma(k, \Theta),$$

Then, to draw from

$$n \sim Poisson(\nu t)$$

we don't need to sample \(\nu\) explicitly!

$$n \sim NegativeBionomial(k, \frac{1}{1 + t \theta})$$

and then update (backpropagate the belief) about \(\nu\) to

\(\nu \sim Gamma(k + n, \frac{\theta}{1 + t \theta})\).

 Instead we can

some References

📰 Senderov, Kudlicka, Ronquist et al. "Universal probabilistic programming offers a powerful approach to statistical phylogenetics." Communications biology 4.1 (2021): 244.

📰 Senderov et al. "TreePPL: A Universal Probabilistic Programming Language for Phylogenetics." bioRxiv (2023): 2023-10.

📰 Kudlicka, Jan, et al. "Probabilistic programming for birth-death models of evolution using an alive particle filter with delayed sampling." Uncertainty in Artificial Intelligence. PMLR, 2020.

📰 Lundén, Daniel, et al. "Automatic Alignment in Higher-Order Probabilistic Programming Languages." ESOP. 2023.

PPLS in genomics

📢 Senderov et al. "A Probabilistic Programming Approach to Investigate the Coevolution of Genes and Phenotypes in Birds." ISMB/ECCB 2023 in Lyon

Q-T-Birds

joint Model pheno-molecular Evolution

Message-passing likelihood calculation

APPLICATIONS

Verification successful:

📰 Talts, Sean, et al. "Validating Bayesian inference algorithms with simulation-based calibration." arXiv preprint arXiv:1804.06788 (2018).

>Propithecus_coquereli/1-1563
ATGGATCATGCTGAAGAAAATGAAATCCTTGCAGCAACCCAGAGGTACTATGTGGAAAGGCCTATCTTTAGT
CATCCGGTCCTCCAGGAAAGACTACACAAAAAGGACAAGGTTTCGGATTCCATTGGGGATAAGCTGAAACAG
GCATTCACATGTACTCCTAAAAAAATAAGAAATATCATTTATATGTTCCTACCCATAACGAAATGGTTACCA
GCATACAAATTCAAGGAGTATGTGTTGGGTGACTTGGTCTCAGGCATAAGTACAGGAGTGCTTCAACTT---
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------TTTTGC
CTAGGTGTCTGTAGGTTCGGATTTGTGGCCATATATCTCACAGAGCCTCTGGTCCGTGGGTTCACCACTGCA
GCAGCTGTGCATGTCTTCACCTCCATGTTAAAATACCTGTTCGGAGTTAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCTCTAGGCGTC
GGTCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAAAGATTTAAAGAGAAATTGCCAGCA
CCCATTCCTTTAGAGTTCTTTGCGGTGGTCATGGGAACTGGCATTTCAGCTGGGTTCAACTTGAAAGAATCT
TACAATGTGGATGTCGTTGGAACACTTCCTCTGGGGCTACTACCTCCGGCCAATCCGGACACCAGCCTCTTC
CACCTCGTATACGTGGATGCCATTGCCATAGCCATCGTTGGATTTTCAGTGACCATCTCAATGGCCAAGACC
TTGGCAAATAAACATGGCTATCAGGTTGACGGCAATCAG---------GAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCGCTCTTCCAGACCTTTTCAATCTCATGCTCCTTGTCTCGAAGCCTTGTTCAGGAGGGA
ACAGGAGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCGTTAATGATTCTGCTGGTCATATTAGCCACTGGA
TTCCTCTTTGAATCATTACCCCAGGCTGTGCTGTCGGCCATTGTGATCGTCAACCTGAAGGGAATGTTTATG
CAGTTCTCAGATCTCCCCTTTTTCTGGAGAACCAGCAAAATAGAGCTGACCATCTGGCTTACCACTTTTGTG
TCCTCCTTGTTCCTGGGATTGGACTACGGTTTGATTACTGCTGTGATCATTGCTCTGTTGACGGTGATTTAC
AGAACACAGAGTCCGAGCTACAAAGTCCTTGGACAGCTTCCCGACACTGATGTATACATTGATATAGACGCA
TATGAGGAGGTGAAAGAAATTCCTGGAATAAAAATATTCCAAATAAATGCCCCAATTTACTATGCAAATAGC
GACTTGTATAGCAATGCATTAAAAAGAAAG------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------CAAGTTGTGAATGACCTCACTCGGAATAGA
TTCTTTGAAAATCCTGCCTTATGGGAGCTGCTGTTCCACAGCATTCATGATGCAGTTCTAGGCAGCCAAGCT
CGAGAGGCACTCGCTGAACAAGAAGCCTCAGCGCTCCCTCCCCAGGATGACTTGGAGCCGAATGCCACT---
------
>Sorex_araneus/1-1137
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------GTGGTAATGGGAACTGGCATTTCAGCTGGGTTTAATTTGAAAGAATCG
TACAATGTGGATGTCGTTGGAACTCTTCCTCTGGGATTACTGCCTCCAGCCAACCCGGATACCAGCCTGTTC
CACCTTGTGTATGTGGATGCCATTGCCATAGCCATCGTTGGATTTTCAGTGACCATCTCTATGGCCAAGACC
TTGGCCAATAAACACGGTTACCAGGTCGATGGCAACCAG---------GAACTCATTGCCCTGGGACTGTGC
AATTCTATTGGTTCCCTCTTCCAGACGTTTTCAATTTCGTGCTCCTTGTCGAGAAGCCTTGTTCAGGAAGGA
ACTGGAGGGAAAACACAGCTTGCAGGTTGTTTGGCTTCATTAATGATCCTGCTGGTCATATTAGCCACCGGA
TTCCTTTTTGAATCATTGCCTCAGGCGGTCCTGTCAGCCATTGTGATCGTCAACCTGAAAGGAATGTTCATG
CAATTCTCAGACCTCCCATTTTTCTGGAGAACCAGCAAGATTGAGTTGACCATTTGGCTCACCACCTTCGTG
TCCTCCTTGTTCCTGGGACTGGATTATGGCTTGATTACTGCCGTGATCATTGCTCTGCTGACTGTGATTTAC
AGGACACAGAGTCCCAGCTACAAAGTTCTTGGACAGCTACCCGACACTGATGTGTACATCGATATTGATGCC
TATGAGGAGGTGAAAGAAATTCCTGGGATAAAAATATTCCAGATAAATGCCCCGATTTATTATGCAAATAGT
GACTTGTATAGCAATGCCCTAAAACGAAAGACTGGAGTGAACCCAGCACTCATAATGGGAGCAAGAAGAAAG
GCCATGAAGAAGTATGCTAAGGAAGTCGGCAATGAAAATATAGCCAACGCAACTGTTGTCAAGGTGGTG---
------------------------------------------------------------------------
------------------------------------------------------------------------
---------------------------------------------------------ATTGTAAAAGAATAT
GGAGATGTCGGCATTTATGTGTATTTAGCAGGATGCAGTGCACAAGTCGTGAACGACCTCACTCGAAATCGG
TTTTTTGAAAACCCGGCCATGCTGGAGCTGCTGTTCCACAGCATCCACGATGCAGTTTTAGGCAGCCTCGTG
CGGGAGGCGCTGGCGGAGCAGGAGACCTCGGCCCCGGCCCCGCAGGAGGACTCGGAGCCCAACGCCACGGCC
GACGCC
>Dipodomys_ordii/1-1911
ATGGATCATGCTGAAGAAAATGAAATCCCTGCAGAAACCCAGAGGTACCATGTGGAAAGGCCCATCTTCAGC
CATCCAGTCCTCCAGGAGAGACTCCACACAAAGGACAAAGTCTCAGAATCCATTGGGGACAAGCTGAAGCAG
GCATTCATATGTACTCCTAAAAAAATAAGAAACATCATCTATATGTTCTTGCCCATTACTAAATGGTTGCCA
GCTTACAAATTCAAGGAGTATGTGCTGGGAGACTTGGTCTCAGGGATAAGCACTGGAGTGCTTCAGCTTCCT
CAAGGCTTGGCCTTCGCAATGCTTGCAGCTGTGCCTCCCATATTCGGCCTCTATTCTTCGTTTTATCCTGTT
ATCATGTATTGTTTTCTTGGAACCTCCAGACACATATCCATAGGTCCTTTTGCTGTTATTAGCTTGATGATT
GGTGGTGTGGCTGTTCGATTAGTACCTGATGACATAGTCATTCCAGGAGGAGTAAATACCACCAATGGTACA
GAAGCCAGAGATGCCCTGAGGGTCAAAGTTGCCATGTCTGTGACCTTGCTTTCGGGAATAATTCAGTTCTGT
CTAGGTGTCTGTAGATTTGGATTCGTGGCCATTTACCTCACAGAGCCTCTGGTCCGTGGATTCACCACTGCA
GCGGCTGTACATGTCTTCACCTCCATGTTAAAATACCTGTTCGGGGTTAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATATTAAAAACCTCAACGTGTGTTCCCTAGGCGTC
GGCCTGATGGTTTTTGGTTTGCTCTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAACTGCCAGCA
CCCATTCCTTTAGAGTTCTTTGCGGTGGTCATGGGCACTGGCATTTCAGCTGGATTTAACTTGCAAGAATCA
TACAATGTGGATGTTGTTGGAACCCTTCCTCTAGGGCTACTCCCTCCAGCCAACCCTGACACCAGCCTCTTC
CACCTCGTGTATGTGGATGCAATTGCCATAGCCATCGTTGGATTTTCAGTGACCATCTCAATGGCCAAGACC
TTGGCAAATAAACATGGCTACCAGGTTGATGGTAATCAG---------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------ACCATCTGGCTGACCACTTTTGTG
TCCTCCTTGTTCCTGGGATTGGACTACGGTTTGATTACTGCTGTCATCATTGCTCTGCTGACTGTGATTTAT
AGAACACAGAGTCCGAGCTACAAAGTCCTGGGACAGCTTCCTGACACTGACGTGTACATTGACATAGACGCA
TACGTGGAGGTGAAAGAAATTCCTGGAATAAAGATATTCCAAATAAATGCTCCAATTTACTATGCAAATAGT
GACTTATACAGCAATGCATTAATAAGAAAGACTGGAGTGAACCCAGCTCTCATAATGGGTGCAAGAAGAAAG
GCCATGAGAAAGTATGCTAAGGAGGTCGGAAATGCAAATATGGCCAACGCGACAGTGGTCAAAGTG------
------------CCTGAAGAAGATGGCACTAAGCCTGAGGAGGAGGATGACGAAGTAAAATATCCTCCAATT
GTCATCAAAAACACATTTCCCGAAGAACTACAAAGATTCATGCCTCCCAGAGAGACTGTCCACACTATCATC
CTGGATTTTACACAAGTCAATTTTATTGATTCTGTTGGAGTAAAAACTCTGGCAGGGATTGTAAAGGAATAC
GGAGATGTCGGTATTTATGTATATTTAGCAGGATGCAGTGCACAAGTAGTGAATGACCTCACTCGGAATAGG
TTTTTTGAAAATCCTGCCTTACAGGAGCTGTTATTCTACAGTATCCATGACGCAGTCCTAGGCAGCCAGCAT
CGAGAGGCACTG---GAACAAGAAGCCTCAGCTTCTCCTCCCCAGGAGGACCTGGAGCCCAACACCACT---
------
>Leptonychotes_weddellii/1-1683
ATGGATCATGCTGAAGAAAATGAAATCCTCGCAGCAAGCCAGAGGTACTATGTGGAAAGGCCTATCTTTAGT
CACCCGGTCCTCCAGGAAAGACTGCACAAGAAGGACAAAATTTCGGATTCCATTGGGGATAAGCTGAAACAG
GCATTCACATGTACTCCTAAGAAGATACGAAATATCATTTATATGTTCCTGCCCATAACAAAGTGGTTACCA
GCATACAAGTTCAAAGAGTATGTGTTGGGTGACTTGGTCTCAGGTATAAGCACAGGGGTGCTTCAGCTTCCT
CAAGGGTTAGCCTTTGCAATGCTCGCTGCCGTACCTCCGGTGTTTGGCCTGTACTCTTCGTTTTACCCTGTT
ATCATGTATTGTTTTTTTGGAACCTCCAGACACATATCCATAGGTCCATTTGCTGTGATTAGCCTGATGATT
GGCGGTGTGGCTGTCCGATTAGTACCAGATGATATAGTCATTCCAGGAGGAGTGAATGCGACCAACGGGACA
GAAGCGAGAGATGCCTTGAGGGTGAAAGTTGCCATGTCTGTGACCTTACTTTCAGGAATCATCCAGTTTTGC
CTAGGTGTCTGTAGGTTTGGATTTGTGGCCATATATCTCACAGAGCCCCTGGTCCGGGGGTTTACCACCGCA
GCAGCTGTGCACGTCTTCACCTCTATGTTGAAATACCTGTTTGGAGTGAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCGGTGTTGCAGAATGTTAGAAACCTCAACGTGTGTTCTCTAGGCGTC
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAGGAGAAATTACCTGCA
CCCATTCCTTTAGAGTTCTTTGCG------------------------------------------------
------------------------------------CTGCTGCCTCCAGCCAACCCGGACACCAGCCTCTTC
CACCTTGTGTACGTGGATGCCATCGCCATAGCCATTGTTGGATTTTCAGTGACCATCTCAATGGCCAAGACC
TTGGCAAATAAACATGGCTACCAGGTTGATGGTAATCAG---------GAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCACTCTTCCAGACTTTCTCCATTTCATGCTCCTTGTCTCGAAGCCTTGTTCAGGAGGGA
ACTGGAGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCGCTAATGATTCTGCTGGTCATATTAGCCACCGGA
TTCCTCTTTGAAGCATTACCCCAGGCTGTGCTGTCGGCCATTGTGATCGTCAACCTGAAAGGAATGTTTATG
CAGTTCTCGGATCTCCCCTTTTTCTGGAGAACAAGCAAAATAGAACTGACCATCTGGCTTACCACTTTCGTT
TCCTCCCTGTTCCTGGGACTGGACTATGGTTTGATTACAGCTGTGATCATCGCTCTGCTAACTGTGATTTAC
AGAACACAGAGTCCCAGCTACAAAGTCCTTGGGCAGCTTCCCGACACAGATGTGTATATTGATACAGACGCA
TATGAAGAG---------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
---------------------------------------GCACAAGTTGTAAATGACCTCACTCAAAATCGA
TTTTTTGAAAACCCTGCCTGGAAGGAGCTGCTGTTCCACAGCATTCACGACGCAGTGTTAGGCAGCCAGCTT
CGGGAAGCACTTGCTGGGCAAGACGCCTCGGCCCTCCCTCCCCAGGAGGACTCAGAGCCCAACGCCACTCCA
GAAGCA
>Mustela_putorius/1-2112
ATGGATCATGCTGAAGAAAATGAAATCCTTGCAGCAAGCCAGAGGTACTATGTGGAAAGGCCTATCTTTAGT
CACCCAGTCCTCCAGGAAAGACTGCACAAGAAGGACAAGATTTCGGATTCCATCGGGGATAAGCTGAAACAG
GCGTTCACATGTACTCCTAAGAAGATACGAAATATCATTTATATGTTCCTGCCCATAACAAAATGGTTACCA
GCATATAAGTTCAAAGAGTATGTGTTGGGTGACTTGGTCTCAGGCATAAGCACGGGGGTCCTTCAGCTTCCT
CAA---------------------------------------------------------------------
------------------------------------------GGTCCATTTGCTGTGATTAGCCTGATGATT
GGCGGTGTGGCAGTCCGATTAGTACCAGATGATATCGTCATCCCAGGAGGAGTAAATGCAACCAACGGCACG
GAAGCAAGAGACGCCTTGAGGGTGAAAGTCGCCATGTCTGTGACCTTACTTTCGGGAATCATCCAGTTTTGC
CTAGGCGTCTGTAGGTTCGGATTTGTGGCCATCTATCTCACCGAGCCCCTGGTCCGGGGCTTTACCACCGCG
GCAGCTGTGCACGTCTTCACCTCCATGTTGAAGTACCTGTTTGGAGTGAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCTCTAGGCGTC
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAATTGCCGGCA
CCCATTCCTTTAGAGTTCTTTGCGGTGGTGATGGGGACTGGCATTTCAGCTGGGTTTAACCTGAAAGAATCG
TACAACGTGGATGTCGTTGGGACACTTCCTCTGGGGCTACTGCCTCCTGCCAACCCGGACACCAGCCTCTTC
CACCTCGTGTACGTGGATGCCATTGCCATAGCCATTGTTGGCTTTTCGGTGACCATCTCAATGGCCAAGACC
TTGGCAAATAAACATGGCTACCAGGTTGATGGCAATCAG---------GAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCACTCTTCCAGACTTTCTCCATTTCATGCTCCTTGTCTCGAAGCCTTGTTCAGGAGGGA
ACTGGAGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCACTAATGATTCTGCTGGTCATATTAGCCACCGGA
TTCCTCTTTGAATCATTACCCCAGGCTGTGCTGTCAGCCATTGTGATCGTCAACCTGAAAGGAATGTTTATG
CAATTCGCAGATCTCCCGTTTTTCTGGAGAACGAGCAAAATAGAACTGACCATCTGGCTTACCACTTTTGTT
TCCTCCTTGTTCCTGGGATTGGACTATGGTTTGATTACAGCTGTGATCATAGCTCTGCTGACTGTGATTTAC
AGAACACAGAGTCCCAGCTACAAAGTCCTTGGACAGCTTCCTGACACTGATGTGTATATCGATATCGACGCA
TATGAAGAGGTGAAAGAAATTCCTGGAATAAAAATATTCCAAATAAATGCCCCAATTTATTATGCAAATAGC
GACTTGTATAGCAGTGCTTTGAAAAGAAAGACAGGAGTGAACCCAGCAGTCATAATGGGAGCGAGAAGAAAG
GCCATGAAGAAGTATGCTAAGGAAGTTGGAAATGCAAATGTGGCTAACGCAACAGTTGTCAAAGTG------
GACGCAGAAGTAGACGGAGAAGATGCCACAAAGCCTGAAGAAGAGAATGATGAAGTAAAATATCCCCCGATA
GTCATCAAGAACACATTCCCTGAGGAACTGCAACGATTTATGCCCCCCGGGGAGAACATTCACACCGTCATT
CTGGATTTCACGCAGGTCAACTTTATTGACTCTGTTGGCGTGAAAACCCTGGCTGGGATTGTTAAAGAATAT
GGAGATGTCGGTATTTATGTGTATTTAGCAGGATGCAGCGCCCAAGTTATAAACGACCTCACTCAGAATCGA
TTTTTTGAGAACCCGGCCTTGAAGGAGCTTCTGTTCCACAGCATTCACGATGCGGTGCTCGGCAGCCAGCTT
CGGGAAGCCCTCGCTGAGCAGGAGGCCTCGGTTCTCCCTCCCCAGGAGGACTCGGAGCCCAACGCCACGGCC
GAAGCA
>Aotus_nancymaae/1-2223
ATGGATCATGCTGAAGAAAATGAAATCCTTGCAGCAACCCAGAGGTACTATGTGGAAAGGCCTATCTTTAGT
CATCCGGTCCTCCAGGAAAGACTACACCAAAAGGACAAGATTCCAGATTCCATTGGGGATAAGCTGAAACAG
GCATTCACATGTACTCCTAAAAAAATAAGAAATATCATTTATATGTTCCTACCCATAACTAAATGGCTGCCA
GCATACAAATTCAAGGAATATGTGTTGGGTGACTTGGTCTCAGGCATAAGCACAGGGGTGCTTCAGCTTCCT
CAAGGCTTAGCCTTTGCAATGCTGGCAGCTGTGCCTCCGATATTTGGCTTGTACTCTTCATTTTATCCTGTT
ATCATGTATTGTTTTTTTGGAACCTCCAGACACATATCCATAGGTCCTTTTGCTGTTATTAGCCTGATGATT
GGTGGTGTGGCTGTTCGATTAGTACCAGATGATATAGTCATTCCAGGAGGAGTAAACGCAACCAATGGCACA
GAAGCCAGAGACGCCTTGAGAGTGAAAGTCGCCATGTCTGTGACCTTACTTTCAGGAATCATTCAGTTTTGC
CTAGGTGTCTGTAGGTTCGGATTTGTGGCCATATATCTCACAGAGCCTCTGGTCCGTGGGTTTACCACCGCA
GCAGCCGTGCATGTCTTCACCTCCATGTTAAAATACCTGTTTGGAGTTAAAACAAAGCGGTACAGTGGAATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTT
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAATTGCCGGCA
CCTATTCCTTTAGAGTTCTTTGCGGTGGTAATGGGAACTGGCATTTCAGCTGGGTTTAACTTGAAAGAATCA
TACAATGTGGATGTCGTTGGAACGCTTCCTCTAGGGCTGCTACCTCCAGCTAATCCGGACACCAGCCTCTTC
CATCTTGTGTACGTAGATGCCATTGCCATAGCCATCGTTGGATTTTCAGTGACCATCTCCATGGCCAAGACC
TTGGCAAATAAACATGGCTACCAGGTTGACGGCAATCAG---------GAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCACTCTTCCAGACCTTTTCAATTTCATGTTCCTTGTCTCGAAGCCTTGTTCAGGAGGGA
ACTGGAGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCATTAATGATTCTGCTGGTCATATTAGCAACTGGA
TTCCTCTTTGAATCATTACCCCAGGCTGTGCTCTCGGCCATTGTGATTGTCAACCTGAAGGGAATGTTTATG
CAGTTCTCAGATCTCCCCTTTTTCTGGAGAACCAGCAAAATAGAGCTGACCATCTGGCTTACCACTTTTGTG
TCCTCCTTGTTCCTGGGATTGGACTATGGTTTGATCACTGCTGTGATCATTGCTCTGCTGACTGTGATTTAT
AGAACACAGAGTCCGAGCTACAAAGTCCTTGGACAGCTTCCTGACACTGATGTGTATATTGATATAGACGCA
TACGAGGAGGTGAAAGAAATCCCTGGAATAAAAATATTTCAAATAAATGCACCAATTTACTATGCAAATAGT
GACTTGTATAGCAATGCATTAAAACGAAAGACTGGAGTGAACCCAGCACTCATCATGGGAGCAAGGAGAAAG
GCCATGCGGAAGTACGCTAAGGAAGTCGGAAATGCAAATATGGCCAACGCAACTGTTGTCAAAGCG------
GATGCAGAAGTAGATGGAGAAGATGCTACCAAGCCTGAAGAAGAGGATGGTGAAATAAAATATCCCCCAATA
GTGATCAAAAGCACATTTCCTGAGGAAATGCAAAGATTTATGCCCCCCGGGGATAACATCCACACTGTGATT
TTGGATTTCACTCAAGTCAATTTTATTGATTCTGTTGGAGTGAAAACTCTGGCAGGGATTGTAAAAGAATAT
GGAGACGTTGGTATATATGTATACTTAGCAGGATGCAGCGCACAAGTTGTGAATGACCTCACTCGGAATAGA
TTTTTTGAAAATCCTGCCCTGTGGGAGCTGCTGTTCCACAGCATTCATGACGCAGTTTTAGGCAGCCAACTC
AGAGAGGCGCTCGCAGAACAGGAAGCCTCGGCTCCCCCTCCACAGGAGGACTTGGAGCCCAATGCTACTCCT
GCTTGA
>Papio_anubis/1-2223
ATGGATCATGCTGAAGAAAATGAAATCCTTGCAGCAACCCAGAGGTACTATGTGGAAAGGCCTATCTTTAGT
CATCCGGTCCTCCAGGAAAGACTACACACTAAGGACAAGGTTCCAGATTCCATTGCGGATAAGCTGAAACAG
GCATTCACATGTACTCCTAAAAAAATAAGAAATATCATTTATATGTTCCTACCCATAACTAAATGGCTGCCA
GCATACAAATTCAAGGAATATGTGTTGGGTGACTTGGTCTCAGGCATAAGCACAGGGGTGCTTCAGCTTCCT
CAAGGCTTAGCCTTTGCAATGCTGGCAGCTGTGCCTCCGATATTCGGCCTGTACTCTTCATTTTATCCTGTT
ATCATGTATTGTTTTTTTGGAACCTCCAGACACATATCAATAGGTCCTTTTGCTGTTATTAGCCTGATGATT
GGTGGTGTGGCTGTTCGATTAGTACCAGATGATATAGTCATTCCAGGAGGAGTAAATGCAACCAATGGCACA
GAGGCCAGAGATGCCTTGAGAGTGAAAGTCGCCATGTCTGTGACCTTACTTTCAGGAATCATTCAGTTTTGC
CTAGGTGTCTGTAGGTTTGGATTTGTGGCCATATATCTCACAGAGCCTCTGGTCCGTGGGTTTACCACTGCA
GCAGCTGTGCATGTCTTCACCTCCATGTTAAAATATCTGTTTGGAGTTAAAACAAAGCGGTACAGTGGAATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTC
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAATTGCCGGCG
CCTATTCCTTTAGAGTTCTTTGCGGTGGTAATGGGAACTGGCATTTCAGCTGGGTTTAACTTGAAAGAATCA
TACAATGTGGATGTCGTTGGAACACTTCCTCTAGGGCTGCTACCTCCAGCCAATCCGGACACCAGCCTCTTC
CACCTTGTGTACGTAGATGCCATTGCCATAGCCATCGTTGGATTTTCAGTGACCATCTCCATGGCCAAGACC
TTAGCAAATAAACATGGCTACCAGGTTGACGGCAATCAG---------GAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCACTCTTCCAGACCTTTTCAATTTCATGCTCCTTGTCTCGAAGCCTTGTTCAGGAGGGA
ACTGGTGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCATTAATGATTCTGCTGGTCATATTAGCAACTGGA
TTCCTCTTTGAATCATTGCCCCAGGCTGTGCTGTCCGCCATTGTGATTGTCAACCTGAAGGGAATGTTTATG
CAGTTCTCAGATCTCCCCTTTTTCTGGAGAACCAGCAAAATAGAGCTGACCATCTGGCTTACCACTTTTGTG
TCCTCCTTGTTCCTGGGATTGGACTATGGTTTGATCACTGCTGTGATCATTGCTCTGCTGACTGTGATTTAC
AGAACACAGAGTCCGAGCTACAAAGTCCTTGGACAGCTTCCTGAAACTGATGTGTATATTGATATAGACGCA
TATGAGGAGGTGAAAGAAATTCCTGGAATAAAAATATTTCAAATAAATGCACCAATTTACTATGCAAATAGT
GACTTGTATAGCAATGCATTAAAACGAAAGACTGGAGTGAACCCAGCAGTCATCATGGGAGCAAGGAGAAAG
GCCATGCGGAAGTATGCTAAGGAAGTCGGAAATGCAAATATGGCCAACGCGACTGTTGTCAAAGCG------
GATGCAGAAGTAGATGGAGAAGATGCTACCAAGCCGGAAGAAGAGGATGGTGAAGTAAAATATCCCCCAATA
GTGATCAAAAGCACATTTCCTGAGGAAATGCAAAGATTTATGCCCCCAGGGGATAACATCCACACTGTCATT
TTGGATTTCACTCAAGTCAATTTTATTGATTCTGTTGGAGTGAAAACTCTGGCAGGGATTGTAAAAGAATAT
GGAGATGTTGGTATATATGTATACTTAGCAGGATGCAGTGCACAAGTTGTGAATGACCTCACTCGGAATAGA
TTTTTTGAAAATCCTGCCCTATGGGAGCTGCTGTTCCACAGCATTCATGATGCGGTTTTAGGCAGCCAACGT
AGAGAGGCACTTGCTGAACAGGAAGCCTTGGCTGCCCCTCCCCAGGAGGACTTGGAGCCCAATGCCACTCCT
CCCATA
>Chlorocebus_sabaeus/1-2220
ATGGATCATGCTGAAGAAAATGAAATCCTTGCAGCAACCCAGAGGTACTATGTGGAAAGGCCTATCTTTAGT
CATCCGGTCCTCCAGGAAAGACTACACACTAAGGACAAGGTTCCAGATTCCATTGCGGATAAGCTGAAACAG
GCATTCACATGTACTCCTAAAAAAATAAGAAATATCATTTATATGTTCCTACCCATAACTAAATGGCTGCCA
GCATACAAATTCAAGGAATATGTGTTGGGTGACTTGGTCTCAGGCATAAGCACAGGGGTGCTTCAGCTTCCT
CAAGGCTTAGCCTTTGCAATGCTGGCAGCTGTGCCTCCGATATTTGGCCTGTACTCTTCATTTTATCCTGTT
ATCATGTATTGTTTTTTGGGAACCTCCAGACACATATCAATAGGTCCTTTTGCTGTTATTAGCCTGATGATT
GGTGGTGTGGCTGTTCGATTAGTACCAGATGATATAGTCATTCCAGGAGGAGTAAATGCAACCAATGGCACA
GAGGCCAGAGATGCCTTGAGAGTGAAAGTCGCCATGTCTGTGACCTTACTTTCAGGAATCATTCAGTTTTGC
CTAGGTGTCTGTAGGTTTGGATTTGTGGCCATATATCTCACAGAGCCTCTGGTCCGTGGGTTTACCACTGCA
GCAGCTGTGCATGTCTTCACCTCCATGTTAAAATATCTGTTTGGAGTTAAAACAAAGCGGTACAGTGGAATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTC
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAATTGCCGGCG
CCTATTCCTTTAGAGTTCTTTGCGGTGGTAATGGGAACTGGCATTTCAGCTGGGTTTAACTTGAAAGAATCA
TACAATGTGGATGTCGTTGGAACACTTCCTCTAGGGCTGCTACCTCCAGCCAATCCGGACACCAGCCTCTTC
CACCTTGTGTACGTAGATGCCATTGCCATAGCCATCGTTGGATTTTCAGTGACCATCTCCATGGCCAAGACC
TTAGCAAATAAACATGGCTACCAGGTTGACGGCAATCAGGAA---AAGGAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCACTCTTCCAGACCTTTTCAATTTCATGCTCCTTGTCTCGAAGCCTTGTTCAGGAGGGA
ACTGGTGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCATTAATGATTCTGTTGGTCATATTAGCAACTGGA
TTCCTCTTTGAATCATTGCCCCAGGCTGTGCTATCCGCCATTGTGATTGTCAACCTGAAGGGAATGTTTATG
CAGTTCTCAGATCTCCCCTTTTTCTGGAGAACCAGCAAAATAGAGCTGACCATCTGGCTTACCACTTTTGTG
TCCTCCTTGTTCTTGGGATTGGACTATGGTTTGATCACCGCTGTGATCATTGCTCTGCTGACTGTGATTTAC
AGAACACAGAGTCCGAGCTACAAAGTCCTTGGACAGCTTCCTGAAACTGATGTGTATATTGATATAGACGCA
TATGAGGAGGTGAAAGAAATTCCTGGAATAAAAATATTTCAAATAAATGCACCAATTTACTATGCAAATAGT
GACTTGTATAGCAATGCATTAAAACGAAAGACTGGAGTGAACCCAGCAGTCATCATGGGAGCAAGGAGAAAG
GCCATGCGGAAGTATGCTAAGGAAGTCGGAAATGCAAATATGGCCAACGCCACTGTTGTCAAAGCA------
GATGCAGAAGTAGATGGAGAAGATGCTACCAAGCCGGAAGAAGAGGATGGTGAAGTAAAATATCCCCCAATA
GTGATCAAAAGCACATTTCCTGAGGAAATGCAAAGATTTATGCCCCCAGGGGATAACATCCACACTGTCATT
TTGGATTTCACTCAAGTCAATTTTATTGATTCTGTTGGAGTGAAAACTCTGGCAGGGATTGTAAAAGAATAT
GGAGACGTTGGTATATATGTATACTTAGCAGGATGCAGTGCACAAGTTGTGAATGACCTCACTCGGAATAGA
TTTTTTGAAAATCCTGCCCTATGGGAGCTGCTGTTCCACAGCATTCATGATGCGGTTTTAGGCAGCCAACGT
AGAGAGGCACTTGCTGAACAGGAAGCCTCGGCTGCCCCTCCCCAGGAGGACTTGGAGCCCAATGCCACT---
------
>Callithrix_jacchus/1-2214
ATGGATCATGCTGAAGAAAATGAAATCCTTGCAGCAACCCAGAGGTACTATGTGGAAAGGCCTATCTTTAGT
CATCCGGTCCTCCAGGAAAGACTACACCAAAAGGACAAGATTCCAGATTCCATTGGGGATAAGCTGAAACAG
GCATTCACATGTACTCCTAAAAAAATAAGAAATATCATTTATATGTTCCTACCCATAACTAAATGGCTGCCA
GCATACAAATTTAAGGAATATGTGATGTCCCATCATATGTCTAGTATTAGCACCAAGGTTTTTAAT---CCC
ACAGGCTTAGCCTTTGCAATGCTGGCAGCTGTGCCTCCGATATTTGGCTTGTACTCTTCATTTTATCCTGTT
ATCATGTATTGTTTTTTTGGAACCTCCAGACACATATCCATAGGTCCTTTTGCTGTTATTAGCCTGATGATT
GGTGGTGTGGCTGTTCGATTAGTACCAGATGATATAGTCATTCCAGGAGGAGTAAATGCAACCAATGGCACA
GAAGCCAGAGACGCCTTGAGAGTGAAAGTCGCCATGTCTGTGACCTTACTTTCAGGAATCATTCAGTTTTGC
CTAGGTGTCTGTAGGTTCGGATTTGTGGCCATATATCTCACAGAGCCTCTGGTCCGTGGGTTTACCACCGCA
GCAGCTGTGCATGTCTTCACCTCCATGTTAAAATACCTGTTTGGAGTTAAAACAAAGCGGTACAGTGGAATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTT
GGGCTGATGGTTTTTGGTTTGCTGCTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAATTGCCAGCA
CCAATTCCTTTAGAGTTCTTTGCGGTGGTAATGGGAACTGGCATTTCAGCTGGGTTTAACTTGAAAGAATCA
TACAATGTGGATGTCGTTGGAACACTTCCTCTAGGGCTGCTACCTCCAGCTAATCCGGACACCAGCCTCTTC
CATCTTGTGTACGTAGATGCCATTGCCATAGCCATCGTTGGATTTTCAGTGACCATCTCCATGGCCAAGACC
TTGGCAAATAAACATGGCTACCAGGTTGATGGCAATCAG---GAAAAGGAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCACTCTTCCAGACCTTTTCAATTTCATGCTCCTTGTCTCGAAGCCTTGTTCAGGAGGGA
ACTGGAGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCATTAATGATTCTGCTGGTCATATTAGCAACCGGA
TTTCTCTTTGAATCGTTACCCCAGGCTGTGCTCTCGGCCATTGTGATTGTCAACCTCAAGGGAATGTTTATG
CAGTTCTCAGATCTCCCCTTTTTCTGGAGAACCAGCAAAATAGAGCTGACCATCTGGCTTACCACTTTTGTG
TCCTCCTTGTTCCTGGGATTGGACTATGGTTTGATCACCGCTGTGATCATTGCTCTGCTGACTGTGATTTAT
AGAACACAGAGTCCGAGCTACAAAGTCCTTGGACAGCTTCCTGACACTGATGTGTATATTGATATAGACGCA
TATGAGGAGGTTAAAGAAATCCCTGGAATAAAAATATTTCAAAAAAATGCACCAATTTACTATGCAAATAGT
GACTTGTATAGCAATGCATTAAAACGAAAGACTGGAGTAAACCCAGCACTCATCATGGGAGCAAGGAGAAAG
GCCATGAGGAAGTACGCTAAGGAAGTTGGAAATGCAAATATGGCCAACGCAACTGTTGTCAAAGCG------
GATGCA---GTAGATGGAGAAGATGCTACCAAGCCTGAAGAAGAGGATGGTGAAATAAAATATCCCCCAATA
GTGATCAAAAGCACATTTCCTGAGGAAATGCAAAGGTTTATGCCCCCCGGGGATAACATCCACACTGTGATT
TTGGATTTCACTCAAGTCAATTTTATTGATTCTGTTGGAGTGAAAACTGTGGCAGGGATTGTAAAAGAATAT
GGAGACGTTGGTATATATGTATACTTAGCAGGATGCAGTGCGCAAGTTGTGAATGACCTCACTCGGAATAGA
TTTTTTGAAAATCCGGCCCTGTGGGAGCTGCTGTTCCACAGCATTCATGACGCAGTTTTAGGCAGCCAACTC
AGAGAGGCGCTCGCAGAACAGGAAGCCTCAGCTCCCCCTCTGCAGGAGGACTTGGAGCCCAATGCTACT---
------
>Pteropus_alecto/1-2220
ATGGATCATGCTGAAGAAAATGAAATCCTTGCAGCAACCCAGAGGTACTATGTGGAAAGGCCTATCTTTAGT
CATCCGGTCCTCCAAGAAAGACTGCACAAGAAAGACAAGATCCCAGATTCCATTGGGGATAAGCTGAAACAG
GCATTCACATGTACTCCTAAGAAAATAAGAAATATCATTTATATGTTCTTACCCATAACTAAGTGGTTGCCA
GCATACAAATTCAAGGAGTATGTGTTGGGTGACTTGGTCTCAGGCATAAGCACAGGAGTGCTTCAGCTTCCT
CAAGGTTTAGCCTTCGCAATGTTGGCAGCTGTGCCTCCGGTGTTTGGCCTGTATTCTTCGTTTTACCCTGTT
ATCATGTATTGTTTTTTCGGAACCTCCAGACACATATCCATAGGTCCGTTTGCTGTTATTAGCCTGATGATT
GGTGGTGTGGCTGTTCGATTAGTCCCAGATGATATAGTCATCCCAGGAGGAGTAAACGCAACCAATGGTACA
GAAGCAAGAGATGCCTTGAGAGTAAAAGTTGCCATGTCTGTGACCTTACTTTCAGGAATCATTCAGTTTTGC
CTAGGAGTCTGTAGGTTTGGGTTTGTGGCCATCTACCTCACAGAGCCCCTGGTGCGTGGGTTCACCACTGCA
GCAGCTGTGCACGTCTTCACCTCCATGCTGAAATATCTGTTCGGCGTTAAAACGAAGCGGTACAGTGGCATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTC
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAATTGCCGGCA
CCCATTCCTTTAGAGTTCTTTGCGGTGGTAATGGGAACTGGCATTTCAGCTGGGTTTAACTTGCATGAATCA
TACAATGTGGATGTTGTTGGAACACTTCCTTTGGGGCTACTACCTCCAGCCAATCCGGACACCAGCCTCTTC
CACCTTGTGTACGTGGATGCCATCGCCATAGCCATTGTTGGATTTTCAGTGACCATCTCAATGGCCAAGACC
TTGGCAAATAAACATGGCTATCAGGTTGATGGCAATCAG---------GAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGTTCACTCTTCCAGACTTTCTCAATTTCATGTTCCTTGTCTCGAAGTCTTGTTCAGGAGGGA
ACTGGAGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCGTTAATGATTCTGATGGTCATATTAGCCACCGGA
TTCCTCTTTGAATCGTTACCCCAGGCTGTACTGTCGGCCATTGTGATCGTCAACCTGAAGGGAATGTTTATG
CAGTTCTCAGATCTCCCCTTTTTCTGGAGAACCAGCAAAATAGAGCTGACCATCTGGCTTACCACTTTTGTT
TCCTCCTTGTTCCTGGGATTGGACTATGGTTTGATTACTGCCGTGATCATCGCACTGATGACTGTGATTTAC
AGAACACAGAGTCCGAGCTACAAAGTCCTTGGACAGCTTCCTGACACTGATGTGTATATTGATATAGACGCA
TATGAGGAGGTGAAAGAAATTCCTGGAATAAAAATATTCCAAATAAATGCCCCAATTTATTATGCAAATAGC
GACTTGTATAGCAACGCATTAAAAAGAAAGACTGGAGTGAACCCGGCACTCATAATGGGAGCAAGAAGAAAG
GCCATGAGGAAGTATGCTAAGGAAGTCGGGAATGCAAATATGGCCAATGCAGCCGTCGTCAAAGCA------
GATGCAGAAGTGGATGGAGAAGATGGTACCAAGCCTGAAGAAGATGAT---GAAGTAAAATATCCTCCAATA
GTCATCAAGAACACATTTCCTGAAGAGCTGCAAAGATTTATGCCCCCAGGGGATAACATTCACACCGTCATT
CTGGATTTTACACAAGTCAATTTTATTGATTCTGTTGGTGTAAAAACTCTGGCAGGGATTGTAAAAGAATAT
GGAGATGTCGGTATTTATGTGTATTTAGCAGGATGCAGTGCACAAGTTGTGAATGACCTCACTCAAAACCAA
TTTTTTGAAAATCCTGCTTTAAGGGAGCTGCTGTTCCACAGTATCCATGATGCAGTTTTAGGCAGCCACGTG
CGAGAGGCGCTGGCTGAGCAGGAAGCCTCAGCCCCTGCAACCCAGGAAGACATGGAGCCTAATGCCACTCCT
GAGGCC
>Otolemur_garnettii/1-2169
ATGGATCATGCTGAAGAAAATGAAATCCTTGCAGCAACCCAGAGGTACTATGTGGAGAGGCCTATCTTTAGC
CATCCAGTCCTCCAGGAAAGACTACACACGAAGGACAAGGTTCCGGATTCCATTGGGGATAAGCTGAAACAG
GCATTCACATGTACCCCTAAAAAAATAAGAAATATCATTTATATGTTCCTACCCATAACTAAGTGGTTGCCA
GCTTACAAATTCAAGGAGTATGTGTTGGGTGACTTGGTCTCAGGCATAAGTACAGGAGTGCTTCAGCTTCCT
CAAGGCTTAGCCTTCGCAATGCTGGCAGCGGTACCCCCGGTATTTGGCCTGTACTCTTCATTTTATCCTGTT
ATCATGTATTGCTTTTTTGGAACCTCCAGACACATATCCATAGGTCCTTTTGCTGTTATTAGCCTGATGATT
GGTGGTGTGGCTGTTCGATTAGTACCAGACGATATAGTCATCCCAGGAGGAGTAAATGCAACCAATGGCACT
GAAGCCAGAGATGCCCTGAGAGTGAAAGTTGCCATGTCTGTGACCTTACTCTCAGGAATCATTCAGTTTTGC
CTAGGTGTCTGCAGGTTCGGATTTGTGGCCATCTATCTCACAGAGCCTCTGGTCCGTGGGTTCACCACCGCA
GCGGCCGTGCATGTCTTCACCTCCATGCTAAAATACCTGTTTGGAGTCAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTATATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCTCTAGGCGTC
GGTCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAAAGATTTAAAGAGAAATTGCCAGCA
CCCATTCCCTTAGAGTTCTTTGCGGTGGTAATGGGAACTGGCATTTCAGCTGGGTTTAACTTGAAAGAATCA
TACAATGTGGATGTTGTTGGAACACTTCCTCTGGGGCTACTACCTCCAGCCAACCCGGATACCAGCCTCTTC
CACCTTGTATACGTGGATGCCATTGCCATAGCCATCGTTGGATTTTCAGTGACCATTTCAATGGCCAAGACC
TTGGCAAATAAACATGGCTATCAGGTTGATGGCAATCAG---GAAAAGGAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCGCTCTTCCAGACCTTCTCCATTTCCTGCTCCTTGTCTCGAAGCCTTGTTCAGGAGGGA
ACTGGAGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCGTTAATGATCCTGCTGGTCATATTAGCCACTGGA
TTCCTCTTTGAATCATTACCACAGGCTGTGCTGTCCGCCATTGTGATCGTCAACCTGAAGGGAATGTTTATG
CAGTTCTCAGATCTCCCCTTTTTCTGGAGAACCAGCAAAATAGAGCTGACCATCTGGCTGACCACGTTTGTG
TCCTCCTTGTTCCTGGGATTGGACTATGGTTTGATTACTGCTGTGATCATCGCTCTGCTGACTGTGATTTAC
AGAACACAGAGTCCGAGCTACAAAGTCCTTGGACAGCTTCCGGACACTGACGTGTATATTGATATAGACACA
TATGAGGAGGTGAAAGAAATTCCTGGAATAAAAATATTTCAAATAAATGCCCCAATTTACTATGCGAATAGT
GACTTGTATAGCAATGCATTAAAAAGAAAGACTGGAGTGAACCCTGCACTAATCATGGGAGCGAGAAGAAAG
GCCATGAGGAAGTATGCCAAGGAAGTCGGAAATGCAAATGTGGCCAATGCAACTGTTGTCAAAGTG------
GATGCAGAAGTAGATGGAGAAGATGGTACCAAGCCTGAAGAAGAGGATGGCGAAGTAAAATATCCCCCCATA
GTCGTCAAAAGCACATTGCCTGAAGAACTGCAAAGATTTATGCCCCCCGGAGATAATATCCACACCATCATT
CTGGATTTCACACAAGTGAATTTTGTTGATTCTGTTGGAGTAAAAACTGTGGCAGGGATT------------
---------------------------------------GCACAAGTAGTGAACGACCTCACTCGAAATAGA
TTTTTTGAAAATCCTGCCCTATGGGAGCTGCTGTTCCACAGTATTCATGATGCAGTGTTAGGCAGCCAACTG
CGGGAGGCGCTCGCTGAACAGGAAGCCTCAGCGCTCCCCCTGCAGGACGACTTGGAGCCCAATGCCACA---
------
>Cricetulus_griseus/1-2211
ATGGATCATGCTGAGGAAAATGAAATCCCTGCAGCAACCCAGAAGTACTACGTGGAAAGGCCTATCTTTAGT
CATCCTGTCCTCCAGGAGAGGCTGCATGTCAAGGACAAGGTCTCAGATTCCATCGGAGATAAGTTGAAACAG
GCATTCACATGTACTCCTAAAAAAATAAGAAACATCATTTACATGTTCCTGCCCATCACTAAGTGGTTGCCA
GCATACAAATTCAAGGAGTATGTTTTGGGTGACTTGGTCTCAGGCATAAGCACTGGGGTGCTTCAGCTTCCC
CAAGGCTTAGCCTTTGCGATGCTGGCAGCTGTGCCTCCAGTGTTTGGCCTGTATTCTTCATTTTACCCTGTT
ATCATGTACTGTTTCTTTGGAACCTCCAGACACATATCAATAGGCCCTTTTGCTGTTATTAGCTTGATGATT
GGTGGTGTGGCAGTTCGGTTAGTACCAGACGATATAGTCATCCCAGGAGGAGTAAATGCAACCAATGGTACT
GAAGCCAGAGATGCGTTAAGAGTGAAAGTCGCCATGTCTGTGACCTTACTTTCAGGGATCATTCAGTTTTGT
CTAGGCGTCTGTAGGTTTGGATTTGTGGCCATCTACCTCACGGAGCCTCTGGTGCGAGGGTTTACCACGGCG
GCCGCTGTGCACGTGTTCACCTCCATGTTAAAATACCTGTTTGGGGTTAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTC
GGCCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAATTGCCAGCA
CCCATTCCTCTAGAGTTCTTTGCTGTGGTGATGGGAACTGGCATTTCCGCAGGGTTTAACTTGCAAGAGTCC
TACAGCGTGGATGTGGTTGGAACTCTTCCTCTAGGACTACTTCCTCCCGCCAACCCGGACACCAGCCTCTTC
CACCTCGTGTATGTGGACGCCATTGCCATAGCCATCGTTGGATTTTCAGTGACCATCTCCATGGCCAAAACC
TTGGCAAATAAGCATGGCTACCAGGTTGATGGCAACCAG---------GAGCTCATCGCCTTGGGGATCTGC
AACTCCATCGGATCTCTCTTCCAGACCTTCTCAATTTCATGCTCCTTGTCTCGGAGCCTTGTTCAGGAGGGG
ACAGGAGGGAAGACACAGCTTGCAGGTTGTCTGGCCTCGTTAATGATTCTACTGGTCATATTAGCCACAGGA
TTCCTCTTTGAGTCACTGCCCCAGGCTGTGCTCTCCGCCATTGTGATCGTCAACTTGAAAGGAATGTTTATG
CAGTTCTCAGATCTGCCCTTCTTCTGGAGAACCAGCAAAATAGAGCTGACCATCTGGCTCACCACCTTCGTG
TCTTCCCTATTCCTGGGGCTGGACTATGGGCTGATTACTGCCGTGATCATTGCCCTGCTGACTGTGATCTAC
AGAACACAGAGTCCGAGCTACAAAGTCCTGGGGCAGCTCCCTGACACGGATGTGTACATTGACATAGATGCA
TATGAGGAGGTGAAAGAAATTCCTGGAATAAAAATATTCCAAATAAATGCCCCAATTTACTATGCAAACAGT
GACTTGTATAGCAACGCATTAAAAAGAAAGACTGGAGTGAATCCAGCACTCATAATGGGAGCAAGACGGAAG
GCCATGAGGAAGTATGCGAAGGAAGTTGGAAATGCCAATGTGGCCAATGCGACTGTTGTCAAAGTG------
GATGCAGAAATAGATGGAGAAGATGTTAAGAAGCCTGAAGAAGAAGATGAGGAAGTAAAATATCCCCCAATA
GTCATCAAAACAACATTTCCTGAAGAGATGCAGAGATTTATGCCCCAG---GAAAATGTTCACACTGTCATT
CTTGACTTTACACAAGTCAATTTTATTGATTCTGTTGGAGTGAAAACTCTGGCTGGGATTGTGAAGGAATAC
GGAGATGTTGGTATTTATGTGTACTTAGCCGGATGCAGCCCACAAGTTGTGAATGACCTCACCCGCAACCGG
TTTTTTGAAAATCCCGCCTTAAAAGAGCTTCTGTTCCACAGTATCCATGATGCTGTCTTAGGCAGCCAGGTC
CGAGAAGCGATGGCCGAGCAAGAAACTTCAGCTCTCTCTCCCCAGGACGACATGGAGCCCAATGCCACA---
------
>Mesocricetus_auratus/1-2211
ATGGATCATGCAGAAGAAAATGAAATCCCTGCAGCAACCCAGAAGTACTACGTGGAGAGGCCCATCTTTAGT
CAACCCGTCCTCCAGGAGAGGCTGCATGTCAAGGACAAGGTCTCAGATTCCATCGGGGATAAGTTGAAACAG
GCATTCACATGCACTCCTAAAAAAATAAGAAACATCATTTACATGTTCTTGCCCATCACTAAGTGGTTACCA
GCGTATAAATTCAAGGAGTATGTGCTGGGTGACTTGGTCTCAGGCATAAGCACTGGGGTGCTCCAACTTCCC
CAAGGCTTGGCCTTCGCAATGCTGGCAGCTGTACCTCCGGTGTTCGGCCTGTATTCCTCATTTTACCCTGTT
ATCATGTACTGTTTCTTTGGAACCTCCAGGCACATATCTATAGGCCCGTTTGCTGTTATTAGCCTGATGATT
GGTGGTGTGGCCGTTCGGTTAGTGCCAGACGATATAGTCATCCCAGGAGGAGTAAATGCAACCAATGGTACA
GAAGCCAGAGATGCATTAAGAGTGAAAGTCGCCATGTCTGTGACCTTACTTTCGGGGATCATTCAGTTTTGC
CTAGGTGTCTGCAGGTTTGGATTTGTGGCCATATACCTCACGGAGCCTCTGGTGCGAGGCTTTACCACCGCG
GCCGCTGTGCATGTGTTCACGTCCATGTTAAAGTACCTGTTTGGGGTTAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTC
GGCCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAGCTGCCAGCA
CCTATTCCTCTAGAGTTCTTTGCTGTGGTGATGGGAACTGGCATTTCCGCAGGGTTTAACTTACAAGAGTCC
TACAGTGTGGATGTGGTTGGAACTCTTCCTCTAGGACTACTTCCTCCCGCCAACCCGGACACCAGCCTCTTC
CACCTCGTGTATGTTGATGCCATTGCCATAGCCATCGTTGGATTTTCAGTGACCATCTCCATGGCCAAAACC
CTGGCAAATAAGCATGGCTACCAGGTTGATGGCAACCAG---------GAGCTCATCGCCTTGGGGATCTGC
AACTCCATCGGATCTCTCTTCCAGACCTTTTCAATTTCATGCTCCTTGTCTCGAAGCCTTGTTCAGGAGGGC
ACAGGAGGGAAGACACAGCTTGCAGGCTGTCTGGCCTCCCTAATGATTCTTCTGGTCATATTAGCCACAGGA
TTCCTCTTTGAGTCCCTGCCCCAGGCTGTGCTCTCCGCCATTGTGATTGTCAACTTGAAAGGGATGTTCATG
CAGTTCTCAGATCTGCCCTTCTTCTGGAGAACCAGCAAAATAGAGCTGACCATCTGGCTTACCACCTTCGTG
TCTTCCCTGTTCCTGGGGCTGGACTATGGGCTGATCACTGCTGTGATCATTGCCCTGCTGACTGTGATCTAC
AGGACACAGAGCCCGAGCTACAAAGTCCTGGGACAGCTCCCCGACACGGATGTGTACATTGACATAGATGCA
TATGAGGAGGTGAAAGAAATCCCTGGAATAAAAATATTCCAAATAAATGCCCCAATTTACTATGCAAACAGT
GACTTGTACAGCAACGCATTAAAAAGAAAGACTGGAGTGAACCCAGCACTCATAATGGGGGCAAGAAGAAAG
GCCTTGAGGAAGTATGCGAAGGAAGTGGGAAACGCCGGTGTGACCAATGCGGCCGTCGTCAAAGCG------
GATGCAGAAATGGATGGAGAAGATGTTAAGAAGCCC---GAAGAAGACGATGAAGTAAAATATCCCCCAATA
GTCATCAAAACAACATTTCCTGAAGAGATGCAGAGATTTATGCCCCAGGGGGAAAATGTTCATACTGTCATT
CTTGACTTTACACAAGTCAATTTTATTGACTCTGTTGGAGTGAAGACTCTGGCTGGGATTGTGAAGGAATAC
GGAGATGTTGGTATTTATGTGTACTTAGCCGGATGCAGCCCACAAGTTGTGAATGACCTCACCCGCAACCGG
TTTTTTGAAAATCCCACCTTAAAAGAGCTTCTGTTCCACAGTATCCATGACGCAGTCTTAGGCAGCCAGGTC
CGAGAGGCGATGGCCGAGCAAGAAACCTCAGCTCCACCTCCCCAGGACGATATGGAGCCCAATGCTACA---
------
>Sus_scrofa/1-2220
ATGGATCATGCTGAAGAAAATGAACTCCTTGCAGCAACCCAGCGGTACTATGTGGAAAGACCTATCTTTAGT
CATCCTGTCCTCCAGGAAAGACTCCACAAGAAGGACAAGATTTCAGATTCCATCGGGGATAAGCTGAAACAG
GCATTCACATGCACTCCAAAGAAAATACGAAATATCATTTACATGTTCCTTCCCATAACCAAGTGGTTGCCT
GCGTACAAATTCAAGGAATATGTGTTGGGTGACTTGGTATCTGGCATAAGCACAGGGGTGCTGCAGCTTCCT
CAAGGTTTGGCCTTTGCAATGTTGGCAGCTGTGCCTCCAGTGTTTGGCCTGTACTCTTCGTTTTACCCTGTT
ATCATGTATTGTTTTTTTGGAACCTCCAGACACATATCCATAGGTCCGTTTGCTGTTATCAGCCTGATGATA
GGCGGCGTGGCTGTTCGGTTAGTTCCAGATGATATAGTCATCCCGGGAGGAGTGAACGCAACCAATGGTACA
GAGGCAAGAGATGCCTTGAGAGTGAAAGTCGCCATGTCTGTGACCTTACTTTCAGGAATCATTCAGTTTTGC
CTAGGTGTCTGTCGGTTTGGGTTTGTGGCCATCTATCTCACGGAGCCCCTGGTCCGTGGGTTTACCACCGCG
GCAGCCGTGCACGTCTTCACCTCCATGTTAAAATACCTGTTTGGCGTTAAAACAAAGCGGTACAGTGGGATC
TTTTCGGTGGTGTATAGTACAGTCGCTGTGCTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTT
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAATTGCCAGCA
CCCATCCCTTTAGAGTTCTTCGCGGTGGTTATGGGAACTGGCATTTCAGCTGGATTTAACTTGAAA---TCA
TACAATGTGGATGTCGTTGGGACCCTTCCTTTAGGGCTGCTCCCTCCAGCCAATCCAGACACCAGCCTCTTT
CACCTTGTGTATGTGGATGCCATCGCCATAGCCATCGTTGGATTTTCAGTGACCATCTCCATGGCCAAGACC
TTGGCAAATAAGCATGGCTACCAGGTTGATGGCAATCAG---------GAGCTCATTGCCCTGGGACTGTGC
AATTCCATCGGCTCACTCTTCCAGACTTTTTCAATTTCATGCTCCTTGTCTCGAAGCCTTGTTCAGGAGGGA
ACTGGAGGGAAGACCCAGCTCGCAGGGTGTTTGGCCTCGTTAATGATTCTGCTGGTCATATTAGCCACTGGA
TTCCTCTTTGAATCGTTACCCCAGGCTGTGCTCTCGGCCATTGTGATCGTCAACCTGAAAGGGATGTTTATG
CAGTTCTCAGATCTCCCCTTTTTCTGGAGAACCAGCAAAATAGAGCTGACCATATGGCTTACCACTTTTGTT
TCCTCCTTGTTCCTGGGGTTGGACTATGGTTTGATTACTGCCGTGATCATCGCGCTGCTGACTGTGATTTAC
AGAACACAGAGTCCGAGCTACAAAGTCCTTGGACAGCTTCCTGAGACTGATGTGTACATTGACATAGACGCG
TATGAGGAGGTGAAAGAAATTCCTGGGATAAAAATATTCCAAATAAATGCTCCAATTTATTATGCAAATAGT
GACTTGTACAGCAATGCCTTAAAAAGAAAGACAGGGGTGAATCCAGCCCTCATAATGGGAGCGAGAAGAAAG
GCCATGAAGAAGTATGCTAAGGAAATGGGGAATGCCAACATGGCCAACGCAGCCGTTGTCAAAGTG------
GATGCAGAAGTAGATGGAGAAGACGGCACCAAGCCTGAGGAAGGGGAGGATGAAATAAAATATCCCCCAATA
GTCATCAAGAGCAAATTTCCTGAGGAACTGCAAAGATTTATGCCCCCAGGCGATAACATCCACACCATCATT
CTGGATTTTACGCAAGTCAATTTTATTGATTCTGTTGGTGTGAAAACTCTGGCCGTGATGGTAAAAGAATAT
GGAGATGTCGGTATTTATGTGTATTTAGCAGGATGCAGTGCACAAGTTGTGGATGACCTCACTCGAAATCGA
TTTTTTGAAAATCCTGCCTTACGGGAGCTGCTCTTCCACAGCATCCATGACGCAGTCCTAGGCAGCCAAGTT
CGAGAGGCAATGGCCGAACGGGATGCCTCGGCCCCTCCTCTCCAGGAGGACTCGGAGCCCAACGCCACTCCA
GAGGCC
>Myotis_davidii/1-1935
ATGGATCATGCTGAAGAAACTGAAATCCTTGCAGCGGCCCAGAAGTACTATGTGGACAGGCCTATCTTTAGT
CATCTGGCCCTCCAGGAAATACTGCACACGAAGGACAAGATTCCGGATTCCATTGGGGATAAGCTAAAACAG
GCATTCACATGTACTCCGAAGAAAATAAGAAATATCATTTATATGTTCTTACCCATAACTAAGTGGTTGCCA
GCATACAAATTCAAGGAGTATGTGTTGGGTGACTTGGTCTCAGGCATTAGCACAGGGGTGCTTCAGCTTCCT
CAAGGCTTAGCCTTCGCAATGTTGGCAGCTGTGCCTCCGGTGTTCGGCCTGTACTCTTCGTTTTACCCTGTT
ATCATGTATTGTTTTTTTGGAACCTCCAGACACATATCCATAGGTCCGTTTGCTGTAATTAGCCTGATGATT
GGCGGCGTGGCTGTTCGATTAGTACCAGATGATATAGTCATCCCGGGAGGAGTAAACGCAACCAATGGTACA
GAAGCCAGAGACGCCTTGAGAGTGAAAGTCGCCATGTCAGTGACCTTACTTGCAGGAATCATTCAGTTTTGC
CTAGGTGTCTGTAGGTTTGGATTTGTGGCCATATACCTCACAGAGCCCCTGGTGCGTGGCTTTACCACGGCG
GCAGCTGTGCATGTCTTCACCTCCATGTTAAAATACCTGTTTGGAGTTAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTC
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAATTGCCGGCA
CCCATTCCGTTAGAGTTCTTTGCGGTGGTGATGGGAACTGGCATTTCAGCTGGGTTCAGCTTGCACGAGTCG
TACAATGTGGACGTCGTTGGGTCACTTCCTCTGGGGCTACTCCCTCCAGCCAATCCGGACACCAGCCTCTTC
CACCTCGTGTACGTGGATGCCATCGCCATAGCCATTGTTGGGTTTTCAGTGACCATCTCGATGGCCAAGACC
TTGGGAAATAAACATGGCTACCAGGTCGATGGCAATCAG---------GAGCTCATTGCGCTGGGACTGTGC
AATTCCATTGGCTCACTCTTCCAGACTTTCGCAATTTCATGCTCCTTGTCTCGAAGCCTTGTTCAGGAGGGC
ACTGGAGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCGTTAATGATTCTGATGGTCATATTAGCCACCGGA
TTCCTCTTTGAATCATTACCCCAGGCTGTGCTGTCGGCCATTGTGATCGTCAACCTGAAGGGAATGTTTATG
CAATTCTCAGATCTCCCCTTTTTCTGGAGAACCAGCAAAATAGAGCTGACCATCTGGCTTACAACTTTCGTT
TCCTCCTTGTTCCTGGGGTTGGACTATGGTTTGATTACTGCTGTCATCATTGCGCTGATGACTGTGATTTAC
AGAACACAGAGTCCGAGCTACAAAGTCCTTGGACAGCTTCCTGACACTGATGTGTATATTGATATAGATGCA
TATGAGGAGGTGAAAGAAATTCCTGGAATTAAAATATTCCAAATAAATGCCCCAATTTATTATGCAAATAGT
GACTTGTATAGCAGTGCATTAAAAAGAAAG------------------------------------------
------------------------------------------------------------------------
GATGGAGAAGTAGACGGGGAAGATGCTACGAAGACTGAAGAAGAGGATGATGAAATAAAATTTCCCCCAGTA
GTCATTAAGACCACAATTCCTGAAGAACTGCAAAGATTTATGCCCCCAGGGGAAAATGTCCACACTGTCATT
CTGGATTTTACACAAGTCAATTTTATCGATTCTGTTGGTGTAAAAACTCTGTCAGGGATTGTAAAAGAATAT
GGAGATGTCGGTATTTATGTGTATTTAGCAGGATGCAGTGCT------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------
>Notamacropus_eugenii/1-1215
ATGGATCACACACAAGAA---GAAATTCTTGTAGCAACCCAAACATATTGCGTGGAGCGACCCATCTATAGC
TATCCAGTCCTACATGGGAAGCTACACAAGAAGGACAAAGTTTCTGATCCTATCGGAGATAAGATAAAACGG
GCTTTAATTTGTACGCCTAAGAAAATAAGGAATATTATCTATATGTTCTTGCCCATATGTAAATGGTTGCCA
GCTTATAAACCAAGGGAATATGTATTTGGGGACTTTGTCTCAGGTATAAGTACAGGGGTGTTACATCTTCCT
CAAGGTTTAGCTTTTGCAATGTTGGCAGCTGTACCTCCAGTATTTGGCCTGTATTCTTCATTTTATCCTGTT
ATCCTGTACTGTTTTTTTGGCACTTCCAGACATGTTTCCATA------------------------------
------------------------------------------------------------------------
---------------------------------------GTAACTTTGCTTTCAGGAATCATTCAGTTTTGC
TTGGGTGTCCTGCGGTTTGGATTTGTGGCCATATACCTAACTGAGCCCTTGGTCCGTGGTTTCACGACTGCA
GCAGCCGTACATGTCTTCACTTCCATGTTAAAATATCTTTTTGGAGTGAAAACAAAGCGGCACAGTGGACCC
TTTTCAGTTGTC------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------CCAGATTCCAGCCTTTTC
CATCTTGTCTATGTGGATGCTATTGCCATTGCAATAGTTGGATTTTCAGTGACCATCTCAATGGCCAAAATC
TTCGCAGTTAAACACGGCTAC---------------------------GAACTCATCGCTCTAGGCATATGC
AATACCATTGGATCACTTTTCCAAACTTTCTCCATTTCATGTTCCTTGTCTCGGAGTCTTGTTCAAGAGAGT
ACTGGAGGAAAGACTCAG------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------ACTATTTGGCTTACCACTTTTGTT
TCCTCCCTGTTCCTTGGGTTAGACTATGGTCTAATTACTGCAGTGATAATTGCCCTGATGACTGTTATTTAC
AGAACACAA---------------------------------------------------------------
---------------------CCTGGGATAAAAATATTCCAAATAAATGCCCCAATTTATTATGCCAATAGT
GACTTGTAT---------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
---------------------------------------------------------ATCCTAAAAGAATAT
GGCGATGTTGGTATTTATGTATATTTAGCTGCATGCAGTGCCCAAGTTGTGAATGACCTCACTCGAAACAGG
TTTTTTGAGAATCCTTGTGTAAAGGAGCTACTATTCCACAGCATTCATGATGCAGTTTTAGGCGCTAAAGTT
CGAGAAGCTCTTGCGCAGCAAGAAGCCTTAGCCCCGCCTCCAGAGGAGGACTCAGAGCCGATTGTTGACCCT
GAGACA
>Tupaia_chinensis/1-2211
ATGGATCATGCTGAAGAAAATGAAATCCTTGCAGCAACGCAGAGGTACTGTGTGGAAAGGCCTATCTTCAGT
AATCCAGTCCTCCAGGAAAGACTGCACAAGAAGGACAAGGTTTCGGAATCCATTGGGGATAAGCTGAAACAG
GCGTTCACATGTACTCCTAAAAAAATAAGGAACATCATTTATATGTTCCTACCCATAACCAAGTGGCTGCCA
GCATATAAATTCAAGGAGTATGTGCTGGGTGACTTGGTCTCAGGCATCAGCACCGGAGTGCTTCAGCTTCCC
CAAGGTTTAGCCTTTGCAATGTTGGCAGCTGTGCCCCCGATATTTGGCCTGTACTCTTCGTTTTATCCTGTT
ATCATGTATTGTTTTTTTGGAACATCCAGACATATATCCATAGGTCCTTTTGCCGTGATTAGCCTGATGATT
GGCGGTGTGGCTGTTCGTTTAGTACCAGATGATATAGTCATTCCAGGAGGAGTAAATGCAACCAATGGGACG
GAAGCCAGGGATGCCTTGAGAGTGAAAGTCGCTATGTCTGTTACTTTACTTTCAGGAATCATTCAGTTTTGC
CTAGGTGTCTGTAGGTTCGGATTTGTGGCCATATATCTCACAGAGCCTCTGGTCCGTGGGTTTACCACTGCA
GCAGCTGTGCATGTCTTCACCTCCATGTTAAAATACCTGTTTGGAGTTAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTT
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAATTACCGGCA
CCCATTCCTTTAGAGTTCTTTGCGGTGGTAATGGGAACTGGCATCTCAGCTGGGTTTAACTTGCACGAATCC
TACAACGTGGATGTCGTCGGAACGCTTCCTCTGGGGCTTCTACCTCCAGCCAATCCGGACACCAGCCTCTTC
CACCTCGTGTATGTAGATGCCATCGCCATAGCCATTGTTGGATTTTCAGTGACCATCTCCATGGCCAAGACC
TTGGCAAATAAACATGGCTACCAGGTCGATGGCAATCAG---------GAACTCATTGCCCTGGGACTGTGT
AATTCCATTGGCTCACTCTTCCAGACCTTTTCGATTTCATGCTCCTTGTCTCGAAGCCTTGTTCAGGAGGGA
ACCGGAGGGAAAACACAGCTTGCAGGTTGTTTGGCCTCATTAATGATTCTGCTGGTCATATTAGCCACTGGA
TTCCTCTTTGAATCACTACCCCAGGCTGTGCTGTCGGCCATTGTGATCGTCAACCTGAAAGGAATGTTTATG
CAGTTCTCAGATCTTCCCTTTTTCTGGAGAACCAGCAAAATAGAGCTGACCATCTGGCTTACTACTTTTGTG
TCCTCCTTGTTCCTGGGACTGGACTATGGTTTGATTACTGCTGTGATCATTGCTCTGCTGACTGTGATTTAC
AGAACACAGAGTCCGAGCTATAAAGTCCTTGGACAGCTTCCCGACACTGATGTGTACATTGATATAGATGCG
TATGAGGAGATAAAAGAAATTCCTGGAATAAAAATATTCCAAATAAATGCCCCAATTTACTACGCAAATAGC
GACTTGTATAGCAATGCATTAAAAAGAAAGACTGGTGTGAATCCTGCACTCATCATGGGCGCAAGAAGAAAG
GCTATGAGGAAGTATGCCAAGGAAGTTGGAAATGCAAATATGGCCAATGCGACTGTTGTCAAAGTG------
GATGCAGAAGTTGATGGAGAAGACGGTACGAAGCCTGAAGAAGGGGATGATGAAGTAAAATATCCCCCAATA
GTCACCAAAAGCACATTTCCTGAAGAACTGCAAAGATTTATGCCCCCT---GATTTATGCCATACTGTCATT
CTGGATTTTACGCAAGTCAATTTTATTGACTCTGTTGGAGTGAAAACTCTGGCAGGGATCGTAAAAGAATAC
GGAGACGTCGGTATTTATGTGTATTTAGCAGGATGCAGCCCACAAGTTGTGAATGACCTCACTCGAAATCGA
TTTTTTGAAAATCCTGCCTTAAAAGAGCTGCTGTTCCACAGCATTCATGATGCAGTTTTAGGCAGCCAGGTT
CGAGAGGCGCTTGCTGAACAAGAAGCCTTAGCAGCCCCTCCCCAGGAGGACTTGGAGCCCAATGACACC---
------
>Tupaia_belangeri/1-1215
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------TTAGCCTTTGCAATGTTGGCAGCTGTGCCCCCGATATTTGGCCTGTACTCTTCGTTTTATCCTGTT
ATCATGTATTGTTTTTTTGGAACATCCAGACATATATCCATAGGTCCTTTTGCCGTGATTAGCCTGATGATT
GGCGGTGTGGCTGTTCGTTTAGTACCAGATGATATAGTCATTCCAGGAGGAGTAAATGCAACCAATGGGACG
GAAGCCAGGGATGCCTTGAGAGTGAAAGTCGCTATGTCTGTTACTTTACTTTCAGGAATTATTCAGTTTTGC
CTAGGTGTCTGTAGGTTCGGATTTGTGGCCATATATCTCACAGAGCCTCTGGTCCGTGGGTTTACCACTGCA
GCAGCTGTGCATGTCTTCACCTCCATGTTAAAATACCTGTTTGGAGTTAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTT
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAATTACCGGCA
CCCATTCCTTTAGAGTTCTTTGCGGTGGTAATGGGAACTGGCATCTCAGCTGGGTTTAATTTGCACGAATCC
TACAACGTGGATGTCGTCGGAACGCTT---------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------GCTGTGCTGTCGGCCATTGTGATCGTCAACCTGAAAGGAATGTTTATG
CAGTTCTCAGATCTTCCCTTTTTCTGGAGAACCAGCAAAATAGAGCTGACCATCTGGCTTACTACTTTTGTG
TCCTCCTTGTTCCTGGGACTGGACTATGGTTTGATTACTGCTGTGATCATTGCTCTGCTGACTGTGATTTAC
AGAACACAG---------------------------------------------------------------
---------ATAAAAGAAATTCCTGGAATAAAAATATTCCAAATAAATGCCCCAATTTACTACGCAAATAGC
GACTTGTATAGCAATGCATTAAAAAGAAAG------------------------------------------
------------------------------------------------------------------------
GATGCAGAAGTTGATGGAGAAGACGGTACGAAGCCTGAAGAAGGGGATGATGAAGTAAAATATCCCCCAATA
GTCACCAAAAGCACATTTCCTGAAGAACTGCAAAGATTTATGCCCCCT---GATTTATGCCATACTGTCATT
CTGGATTTTACGCAAGTCAATTTTATTGACTCTGTTGGAGTGAAAACTCTGGCAGGGATCGTAAAAGAATAC
GGAGACGTCGGTATTTATGTGTATTTAGCAGGATGCAGC---------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------
>Jaculus_jaculus/1-1878
ATGGATCATGCTGAGGAAAATGAAATCCCTGCGGCAGCCCAGACATACTGCGTGGAAAGGCCCATCTTTAGT
CACCCAGTCCTTCAGGAAAGACTGCACCCAAAGGACAAGGTCTCTGATTCCATCGGGGACAAGCTGAAACAG
GCATTCACATGTACACCTAAAAAAATAAGAAATATCATTTACATGTTTCTGCCCATAACGAAGTGGTTGCCG
GCATACAAGTTCAAGGAGTATGTGTTGGGCGACTTGGTCTCAGGCATAAGTACTGGAGTTCTTCAGCTTCCT
CAA---------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------------
------------------------------------------------------------------TTTTGC
CTAGGTGTCTGCAGATTTGGATTTGTGGCCATATATCTCACAGAGCCTCTGGTCCGAGGGTTCACCACCGCA
GCTGCCGTTCATGTCTTCACCTCCATGTTAAAATACCTGTTCGGGGTTAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTC
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGAAAGGAGTTTAATGAGAGATTTAAAGAGAAACTGCCAGCA
CCCATTCCTCTAGAGTTCTTTGCGGTGGTAATGGGAACTGGCATTTCAGCTGGATTTAACTTGCAAGAATCA
TACAATGTGGATGTCGTTGGAACACTTCCTCTGGGGCTGCTCCCTCCGGCCAACCCGGACACCAGTCTCTTC
CACCTCGTGTATGTGGACGCCATTGCCATCGCCATCGTGGGATTCTCAGTGACCATCTCCATGGCCAAGACC
TTGGCAAATAAGCATGGCTACCAGGTTGATGGCAATCAG---------GAGCTCATTGCCTTGGGACTGTGC
AATTCCATTGGATCTCTCTTCCAGACCTTTTCGATTTCTTGTTCCTTGTCCCGAAGCCTTGTTCAGGAAGGA
ACCGGAGGGAAGACACAGCTTGCAGGGTGCTTGGCCTCGTTGATGATTCTGCTAGTCATATTAGCCACTGGC
TTTCTCTTTGAATCATTACCCCAGGCGGTGCTGTCGGCCATTGTGATTGTCAACCTGAAGGGAATGTTTATG
CAGTTCTCAGACCTGCCCTTCTTCTGGAGGACCAGCAAGATCGAGCTGACTATCTGGCTTACCACTTTCGTG
TCATCCTTGTTCCTGGGACTGGACTACGGTTTGATTACCGCAGTGATCATTGCCCTGCTGACCGTCATTTAC
AGAACCCAGAGTCCAAGCTACAAAGTCCTGGGACAGCTTCCCGACACCGATGTATACATTGATATAGACGCA
TATGAGGAGGTGAAAGAAATTCCTGGAATAAAAATATTCCAGATAAATGCTCCAATTTACTATGCAAATAGT
GACTTGTATAGCAACGCATTAAAAAGAAAGACTGGCGTGAACCCAGCACTCATAATGGGAGCAAGAAGAAAG
GCCATGAGGAAATATGCTAAGGAAGTTGGAAATGCAAATATGGCCAATGCAACTGTGGTCAAAGTG------
GATGCGCAAGTAGACGGAGAAGACGGTACCAAGCCTGAAGAGGAGGAGGATAACGTCAAATATCCTCCCATA
GTCATTAAGAGCACGTTTCCTGAAGAAATTCAAAGATTTATGCCCCCG---GAAACTGTCCACACTGTCATT
CTAGATTTCACTCAAGTCAATTTCATCGATTCTGTTGGAGTGAAAACTGTAGCCGGG---------------
---------------------------------------GCACAAGTTGTGAATGACCTCACTCGCAATAGA
TTTTTTGAAAATCCTGCCTTAAAGGAATTACTGTTCCATAGCATCCATGATGCGGTTTTAGGCAGCCAAGTT
CGAGAGGCCCTGGCTAAGCAAGAAACCTCTGCCCCACCTTCTCAAGAGGATTTGGAGCCGAATGCTACT---
------
>Ochotona_princeps/1-2052
---------------------------------------------------GTGGAGAGGCCCATCTTCAGC
CATCCGGTCCTGCAGGAGCGGCTGCACACCAAGGACAAGGTTGCCGACTCCATCGGCGATAAGCTGAAACAG
GCCTTCACATTCACTCCCAAGAAAATCAGGAATATCATCTACATGTTCCTGCCCATCACTAAATGGCTACCA
GCATACAAATTCAAGGAGTATGTGCTGGGGGACTTGGTGTCCGGCATAAGCACAGGGGTGTTGCAGCTGCCT
CAG---------------------------------------------------------------------
---------------------------------------------CCCTTCGCTGTCATTAGCCTGATGATT
GGTGGTGTGGCCGTTCGACTGGTCCCCGATGACATAGTCATCCCAGGAGGAGTCAACAGCACCAATGGGACA
GAAGCCAGGGACGCCTTGCGAGTCAAAGTCGCCATGTCCGTGACCTTGCTTTCAGGCATCATTCAGTTTTGC
CTAGGTGTGTGTAGGTTTGGATTCGTGGCCATCTACCTCACAGAGCCCCTAGTGCGTGGCTTCACCACCGCG
GCCGCCGTACACGTGTTCACCTCCATGCTGAAATACCTCTTTGGAGTTAAAACCAAGCGGTACAGTGGGATC
TTTTCGGTGGTGTATAGTACAGTCGCTGTATTGCAGAATATTAAAAACCTCAACGTGTGTTCCCTAGGCGTC
GGGCTCATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAAATGCCGGCG
CCCATCCCTTTAGAGTTCTTTGCGGTAGTCATGGGGACGGGCATTTCAGCTGGGTTTAACTTGAAAGAATCA
TACAACGTGGACGTCGTTGGAACACTCCCTCTGGGGCTGCTGCCTCCAGCCAACCCAGACACCAGCCTCTTC
CACCTTGTGTACGTGGATGCCATCGCCATTGCCGTCGTTGGCTTCTCAGTGACCATCTCCATGGCCAAGACC
TTGGCAAATAAACATGGCTACCAGGTGGATGGCAATCAG---------GAGCTCATTGCCCTGGGACTGTGC
AACTCCATCGGCTCACTCTTCCAGACCTTCTCGATTTCCTGCTCCCTGTCTCGGAGCCTTGTACAGGAGGGA
ACCGGAGGGAAGACACAGCTTGCAGGTTGTTTAGCCTCGCTGATGATTCTGCTGGTCATCCTAGCCACGGGA
TTCCTGTTTGAATCTTTGCCACAGGCTGTGCTCTCGGCCATTGTCATAGTCAACCTGAAGGGGATGTTCATG
CAGTTCGCGGACCTCCCGTTCTTCTGGAGAACCAGCAAGATAGAGCTGACCATCTGGCTCACCACCTTCGTG
TCCTCCTTGTTCCTGGGGTTGGACTATGGTCTCATCACTGCCGTCATCATCGCCTTGCTGACCGTGATTTAC
AGAACCCAGAGTCCGAGCTACAAAGTCCTTGGACAACTTCCCGAAACTGACGTGTATATTGACATAGACGCG
TTTGAGGAGATCAAAGAAATTCCTGGAATAAAAATCTTCCAAATAAATGCCCCAATTTACTACGCCAACAGC
GACTTGTATAGCAACGCGCTCAAGAGAAAGACCGGCGTGGACCCAGCGGTCATCATGGGCGCCAGGAGGAAG
GCCATGCGGAAGTACGCAAAGGAAGTCGGGAATGTGAACATGGCCAGCGCCATCATGGTCAAGCCGGCCCAG
GATGCGGAAGTTGACGGGGAGAGCGCC---AAGCCCGAGGACGACGACGGCGAGGTGAAATTCCCTCCCATC
GTGGTCAGGGGCGCGTTTCCGGAGGAGCTGCAACGTTTCATGCCCCCCCGCGAGCACATCCACACCATCATC
CTGGACTTCACGCAGGTCAACTTCATCGATTCCGTGGGCGTGAAGACCCTGGCAGGGATCGTGAAGGAGTAC
GGAGACGTGGGCATTTACGTCTACTTGGCAGGCTGCAGCGCCCAGGTCGTGACTGACCTCACTCAAAACCGA
TTCTTTGAGAATCCCGCCTTGAAGGAGCTGCTCTTCTACAGCATCCACGATGCGGTCTTGAGCAGCCAGGTC
CGCGAAGCCCTGGCCGCGCAGGAAGCCCTGGCCGCGCCTCCCCAGGAGGATATGGAGCCCAAGGCCACC---
------
>Ailuropoda_melanoleuca/1-2223
ATGGATCATGCAGAAGAAAATGAAATCCTCGCAGCAAGCCAGAGGTACTATGTGGAAAGGCCTATCTTCAGT
CACCCGGTCCTCCAGGAAAGACTGCACAAGAAGGACAAGATTTCGGATTCCATCGGGGATAAGCTGAAACAG
GCATTCACATGTACTCCCAAGAAGATACGAAATATCATTTATATGTTCCTGCCCATAACGAAGTGGTTACCG
GCATACAAGTTCAAAGAGTATGTGTTGGGTGACTTGGTCTCAGGCATAAGCACAGGGGTGCTCCAGCTTCCT
CAAGGGTTAGCCTTTGCGATGCTAGCAGCTGTGCCTCCGGTGTTTGGCCTGTACTCTTCATTTTACCCTGTT
ATCATGTATTGTTTTCTTGGAACCTCCAGACACATATCCATCGGTCCATTTGCTGTGATCAGCCTGATGATT
GGCGGTGTGGCCGTTCGATTAGTACCAGACGATATAGTCATTCCAGGAGGAGTAAATGCAACCAATGGTACG
GAAGCAAGAGACGCCTTGAGGGTGAAAGTCGCCATGTCTGTGACCTTACTCTCGGGAATCATCCAGTTTTGC
CTAGGTGTCTGTAGGTTTGGATTTGTGGCCATATATCTCACCGAGCCCCTGGTCCGGGGGTTCACCACCGCG
GCCGCTGTGCACGTCTTCACTTCCATGTTGAAATACCTGTTTGGAGTGAAAACAAAGCGGTACAGTGGGATC
TTTTCGGTGGTGTATAGTACGGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCTCTAGGCGTC
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAACTACCGGCA
CCCATTCCTTTAGAGTTCTTTGCGGTGGTGATGGGGACTGGCATTTCAGCTGGGTTTAACCTGAAAGAATCC
TACAATGTGGATGTCGTCGGGACACTTCCTCTGGGGCTACTGCCTCCAGCCAACCCGGACACCAGCCTCTTC
CACCTTGTATACGTGGATGCTATCGCCATAGCCATTGTTGGATTTTCAGTGACCATCTCAATGGCCAAGACT
TTGGCAAGTAAACATGGCTACCAGGTTGATGGCAATCAGATGGAAAAGGAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCACTCTTCCAGACTTTCTCCATTTCATGCTCCTTGTCTCGAAGCCTTGTTCAGGAGGGA
ACTGGAGGGAAGACGCAGCTTGCGGGTTGTTTGGCCTCACTAATGATTCTGCTGGTCATATTAGCCACTGGA
TTCCTCTTTGAATCATTACCCCAGGCTGTGCTGTCGGCTATTGTGATTGTCAACCTGAAAGGAATGTTTATG
CAATTCTCAGATCTCCCCTTTTTCTGGAGAACGAGCAAAATAGAACTGACCATCTGGCTCACCACTTTTGTT
TCCTCCTTGTTCCTGGGATTGGACTATGGTTTGATTACAGCTGTGATCATCGCTCTGCTGACTGTGATTTAC
AGAACACAGAGTCCCAGCTACAAAGTCCTTGGACAGCTTCCCGACACGGATGTGTATATCGATATAGACGCA
TATGAAGAGGTGAAAGAAATTCCTGGAATAAAAATATTCCAAATAAATGCCCCAATTTATTATGCAAATAGC
GACTTATATAGCAGTGCTTTGAAAAGAAAGACTGGAGTGAACCCAGCAGTCATAATGGGAGCGAGAAGAAAG
GCCATGAAGAAGTATGCCAAGGAAGTTGGAAATGCAAATGTGGCCAATGCAAACGTTGTCAAAGTG------
GATGCAGAAGTCGATGGAGAAGATGCCACGAAGCCTGAAGACGAGGGTGATGAAGTAAAATATCCCCCAATA
GTCATCAAGAGCACACTCCCTGAGGAACTGCAAAGATTCATGCCCCCGGGGGATAACGTCCACACCATCATT
CTGGATTTTACGCAGGTCAACTTTATTGACTCTGTTGGCGTGAAAACCCTGGCTGGGATTGTAAAAGAATAT
GGAGATGTCGGTATTTATGTGTATTTAGCAGGATGCAGCGCACAAGTTGTAAACGACCTCACTCAAAATCGA
TTTTTTGAAAATCCTGCCTTAAAGGAGCTGCTGTTCCACAGCATTCACGATGCAGTTCTAGGCAGCCAGCTT
CGGGAAGCGCTTGCTGAGCAAGAAGCCTCGGCTCCTCCTCCGCAGGAGGACTCGGAGCCCAACGCCACT---
------
>Canis_familiaris/1-2220
ATGGATCATGCTGAAGAAAATGAAATCCTCACAGCAAGCCAGAGGTACTATGTGGAAAGACCTATCTTTAGT
CACCCGGTCCTCCAGGAAAGACTGCACAAGAAAGACAAGATTTCGGATTCCATCGGGGATAAGCTGAAACAG
GCATTCACGTGTACTCCTAAGAAGATACGAAATATCATTTATATGTTCCTGCCCATAACTAAGTGGTTGCCA
GCATACAAGTTCAAAGAGTATGTGTTGGGTGACTTGGTCTCAGGCATAAGCACAGGGGTACTTCAGCTTCCT
CAAGGGTTAGCCTTTGCAATGCTGGCTGCTGTGCCTCCCGTGTTTGGCCTGTACTCTTCATTTTACCCTGTT
ATCATGTATTGTTTCCTTGGAACTTCCAGACACATATCCATAGGTCCATTTGCTGTGATTAGCCTGATGATT
GGCGGTGTGGCTGTTAGATTAGTCCCTGATGATATAGTCATTCCAGGAGGAGTAAATGCGACCAATGGCACA
GAGGCAAGAGATGCCTTGAGAGTGAAAGTCGCCATGTCTGTGACCTTACTTTCAGGAATCATCCAGTTTTGC
CTAGGTGTCTGTAGGTTTGGATTTGTGGCCATATATCTCACAGAGCCCCTGGTCCGTGGGTTTACCACCGCG
GCAGCTGTGCATGTCTTCACCTCCATGTTAAAATACTTGTTTGGAGTGAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCTCTAGGCGTC
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAATTGCCGGCA
CCCATTCCTTTAGAGTTCTTTGCGGTGGTGATGGGAACTGGCATTTCAGCTGGGTTTAACTTGAAAGAGTCA
TACAACGTGGATGTCGTCGGGACACTTCCACTGGGGCTACTACCTCCAGCCAACCCGGACACCAGCCTCTTC
CACCTTGTGTACGTGGATGCCATCGCCATAGCCATTGTTGGATTTTCAGTGACCATATCAATGGCCAAGACC
CTGGCAAATAAACATGGCTACCAGGTTGATGGCAATCAG---AAAAAGGAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCACTCTTCCAGACTTTCTCCATTTCGTGCTCCTTGTCTCGAAGCCTTGTTCAGGAGGGA
ACCGGAGGCAAGACACAGCTTGCAGGTTGTTTGGCCTCACTAATGATTCTGCTGGTCATATTAGCCACCGGA
TTCCTCTTCGAATCATTACCCCAGGCTGTGCTGTCGGCCATTGTGATTGTCAACCTGAAAGGAATGTTTATG
CAATTCTCAGATCTCCCCTTTTTCTGGAGAACAAGCAAAATAGAACTGACCATCTGGCTTACCACTTTTGTT
TCCTCCTTGTTTCTGGGGCTGGACTATGGTCTGATTACAGCTGTGATCATTGCTCTGCTAACTGTGATTTAC
AGAACACAGAGTCCCAGCTACAAAGTCCTTGGACAGCTTCCCGACACGGATGTGTACATTGATATAGATGCC
TATGAGGAGGTGAAAGAAATTCCTGGAATAAAAATATTCCAAATAAATGCTCCAATTTATTATGCAAATAGC
GACTTGTATAGCAATGCTTTGAAAAGAAAGACTGGAGTGAACCCAGCAGTCATAATGGGAGCAAGAAGAAAG
GCCATGAAGGAGTATGCCAAGGAAGTTGGAAATGCAAATGTGGCCAATGCAACTGTTGTCAAAGTG------
GATGCAGAAGTGGATGGAGAAGATGCCACGAAACCCGAACAAGAGGATGATGAAGTAAAATATCCCCCAATA
GTCATCAAGAGCACTTTCCCTGAAGAACTGCAAAGATTTATGCCCCCTGGGGATACCATCCACACCGTCATT
CTGGATTTTACCCAAGTCAATTTTATCGATTCCGTTGGTGTCAAAACCCTGGCTGGGATTGTAAAAGAATAT
GGAGATGTCGGTATTTATGTGTATTTAGCAGGATGCAGCGCACAAGTTGTAAACGACCTCACTCAAAATCGA
TTTTTTGAAAACCCTGCGTTAAAGGAGCTGCTGTTCCACAGCATCCACGATGCAGTCTTAGGCAGCCAACTT
CGGGAAGCACTGGCTGAACAAGAAGCCTCGGCTCTTCCTCCCCAGGAGGACTCCGAGCCCAACGCCACT---
------
>Enhydra_lutris_kenyoni/1-2223
ATGGATCATGCTGAAGAAAATGAAATCCTCGCAGCAAGCCAGAGGTACTATGTGGAAAGGCCTATCTTTAGT
CACCCCATCCTCCAGGAAAGACTGCACAAGAAGGACAAGATTTCGGATTCCATCGGGGATAAGTTGAAACAG
GCATTCACATGTACTCCTAAGAAGATACGAAATATCATTTATATGTTCCTGCCCATAACAAAATGGTTACCA
GCATACAAGTTCAAAGAGTATGTGTTGGGTGACTTGGTCTCAGGCATAAGCACAGGGGTCCTTCAGCTTCCT
CAAGGGTTAGCCTTTGCAATGCTGGCTGCTGTGCCTCCCGTGTTTGGCCTGTACTCTTCATTTTATCCTGTT
ATCATGTATTGTTTTTTTGGAACCTCCAGACACGTATCCATAGGTCCATTTGCTGTGATTAGCCTGATGATT
GGCGGCGTGGCTGTCCGATTAGTACCAGATGATATCGTCATCCCAGGAGGAGTAAATGCAACCAACGGCACG
GAAGCAAGAGACGCCTTGAGGGTGAAAGTCGCCATGTCTGTGACCTTACTTTCAGGAATCATCCAGTTTTGC
CTAGGTGTCTGTAGGTTCGGATTTGTGGCCATATATCTCACCGAGCCCCTGGTCCGGGGCTTTACCACCGCA
GCAGCTGTGCACGTCTTCACCTCCATGTTGAAGTACTTGTTTGGAGTGAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCTCTAGGCGTC
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAATTGCCGGCA
CCCATTCCTTTAGAGTTCTTTGCGGTGGTGATGGGGACTGGCATTTCAGCTGGGTTTAACCTGAAAGAATCG
TACAACGTGGATGTCGTCGGGACACTTCCTCTGGGGCTACTGCCTCCTGCCAACCCGGACACCAGCCTCTTC
CACCTCGTGTACGTGGATGCCATCGCCATAGCCATTGTTGGCTTTTCCGTGACCATCTCAATGGCCAAGACC
TTGGCAAGTAAACATGGCTACCAGGTTGATGGCAATCAG---------GAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCACTCTTCCAGACTTTCTCCATTTCATGCTCCTTGTCTCGAAGCCTTGTTCAGGAGGGA
ACTGGAGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCACTAATGATTCTGCTGGTCATATTAGCCACCGGA
TTCCTCTTTGAATCATTACCCCAGGCTGTGCTGTCGGCCATTGTGATCGTCAACCTGAAAGGAATGTTTATG
CAATTCGCAGATCTCCCGTTTTTCTGGAGAACGAGCAAAATAGAACTGACCATCTGGCTTACCACTTTTGTT
TCCTCCTTGTTCCTGGGATTGGACTATGGTTTGATTACAGCTGTGATCATCGCTCTGCTGACTGTGATTTAC
AGAACACAGAGTCCCAGCTACAAAGTCCTTGGACAGCTTCCTGACACTGATGTGTACATCGATATCGACGCA
TATGAAGAGGTGAAAGAAATTCCTGGAATAAAAATATTCCAAATAAATGCCCCAATTTATTATGCAAATAGT
GACTTGTATAGCAGTGCTTTGAAAAGAAAGACAGGAGTGAACCCAGCACTCATAATGGGAGCGAGAAGAAAG
GCCATGAAGAAGTATGCTAAGGAAGTTGGAAATGCAAATGTGGCCAACACAACCGTTGTCCAAGTG------
GACGCGGAAGTAGACGGAGAAGATGCCACAAAGCCTGAAGAAGGGAATGATGAAGTAAAATATCCCCCGATA
GTCATCAAGAGCACATTCCCTGAGGAACTGCAAAGATTTATGCCCCCCGGGGAGAATATTCACACCATCATT
CTGGATTTCACGCAGGTCAACTTTATTGACTCTGTTGGCGTGAAAACCCTGGCTGGGATTGTTAAAGAATAT
GGAGATGTCGGTATTTATGTGTATTTAGCAGGATGCAGCGCCCAAGTTGTAAACGACCTCACTCAGAATCGA
TTTTTTGAGAACCCGGCCTTGAAGGAGCTTTTGTTCCACAGCATTCACGATGCGGTGCTCAGCAGCCAGCTT
CGGGAAGCCCTCGCTGAGCAGGAGGCCTCGGCTCTCCCTCCCCAGGAGGACTCGGAGCCCAACGCCACTGCC
GAAGCA
>Felis_catus/1-2223
ATGGATCATGCTGAAGAAAATGAAATCCTTGCAGCAAGCCAGAGGTACTATGTGGAAAGGCCTATCTTCAGC
CATCTGGTCCTCCAGGAAAGACTTCACAAGAAGGACAAGATTTCAGATTCCATCGGGGATAAGCTGAAACAG
GCATTCACATGTACTCCTAAGAAGATACGAAATATCATTTATATGTTCCTGCCCATAACTAAATGGTTGCCC
GCGTACAAATTCAAAGAGTATGTGTTGGGTGACTTGGTCTCAGGCATAAGCACAGGGGTACTTCAGCTTCCT
CAAGGGTTAGCCTTTGCAATGCTGGCTGCCGTGCCTCCGGTGTTTGGCCTGTACTCTTCATTTTATCCTGTT
ATCATGTATTGTTTTTTTGGAACCTCCAGACATGTATCCATAGGTCCATTCGCTGTTATTAGCCTGATGATT
GGTGGTGTGGCTGTTCGATTAGTACCAGATGATATAGTTATTCCAGGAGGGGTAAATGCGACCAATGGTACG
GAAGCAAGAGATGCCTTGAGAGTGAAAGTCGCCATGTCCGTGACCTTACTTTCAGGAATCATCCAGTTTTGC
CTAGGTGTCTGTAGGTTTGGATTTGTGGCCATATATCTTACGGAGCCCCTGGTCCGTGGGTTTACCACCGCG
GCTGCTGTGCACGTCTTCACCTCCATGTTAAAATACCTGTTTGGAGTTAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTC
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAGGAGAAATTACCGGCA
CCTATTCCTTTAGAGTTCTTTGCGGTGGTGATGGGAACTGGCATTTCAGCTGGGTTTAACTTGCAAGAATCG
TACAATGTGGATGTCGTCGGGACACTTCCTCTGGGGCTACTACCTCCAGCCAACCCGGACACCAGCCTCTTC
CACCTCGTGTACGTGGATGCCATCGCCATAGCCATTGTTGGATTTTCAGTGACCATCTCAATGGCCAAGACC
TTGGCAAATAAACATGGCTACCAGGTGGATGGCAATCAG---------GAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCACTCTTCCAGACTTTCTCAATTTCATGCTCCTTATCTCGAAGCCTTGTTCAAGAGGGG
ACTGGAGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCACTAATGATTCTGCTGGTCATATTAGCCACCGGG
TTCCTCTTCGAATCATTGCCCCAGGCTGTGCTGTCGGCCATTGTGATTGTCAACCTGAAAGGAATGTTCATG
CAATTCTCAGATCTCCCCTTTTTCTGGAGAACGAGCAAAATAGAACTGACCATTTGGCTGACCACTTTTGTT
TCCTCCTTGTTCCTGGGATTGGACTATGGTTTGATCACAGCTGTGATCATCGCTCTGCTGACTGTGATTTAC
AGAACCCAGAGTCCCAGCTACAAAGTGCTTGGACAGCTTCCTGACACTGACGTGTATATTGATATAGATGCA
TATGAGGAGGTGAAAGAAATTCCTGGAATAAAAATTTTCCAAATCAATGCCCCAATTTATTATGCAAATAGC
GACTTATATAGCAATGCTTTAAAAAGAAAGACTGGCGTGAACCCAGCACTCATAATGGGAGCAAGAAGAAAG
GCCATGAAGAAGTATGCTAAGGAAGTTGGAAATGCAAATATGGCCAATGCAACTGCTGTCAAAGTG------
GATGCAGAAGTCGATGGAGAAGATGCCACGAAGCCTGAAGAAGAGGATGACGAAGTAAAATACCCCCCAATA
GTCATCAAGAGCACATTTCCTGAAGAAATGCAAAGATTTATGCCCCCAGGGGATAACATCCACACCATCATT
CTGGATTTTACACAAGTCAATTTTATTGACTCTGTTGGTGTAAAAACTCTGGCCGGGATTGTAAAAGAATAT
GGAGATGTCGGTATTTATGTGTATTTAGCAGGATGCAGCGCACAAGTTGTGAATGACCTCACTCAAAATCGA
TTCTTTGAAAATCCTGCCTTGAAGGAGCTGCTGTTCTACAGCATTCATGATGCAGTTTTAGGCAGCCAGCTT
CGGGAGGCGCTTGCCGAGCAAGAAGCCACCGCTGCCCCTCCGCAGGAGGACTCAGAACCCAACGCCACTCCA
GAAGCT
>Acinonyx_jubatus/1-2223
ATGGATCATGCTGAAGAAAATGAAATCCTTGCAGCAAGCCAGAGGTACTATGTGGAAAGACCTATCTTCAGC
CATCTGGTCCTCCAGGAAAGACTTCACAAGAAGGACAAGATTTCAGATTCCATCGGGGATAAGCTGAAACAG
GCATTCACATGTACTCCTAAGAAGATACGAAATATCATTTATATGTTCCTGCCCATAACTAAGTGGTTGCCC
GCGTACAAATTCAAAGAGTATGTATTGGGTGACTTGGTCTCAGGCATAAGCACAGGGGTACTTCAGCTTCCT
CAAGGGTTAGCCTTTGCAATGCTGGCTGCCGTGCCTCCGGTGTTTGGCCTGTACTCTTCATTTTATCCTGTT
ATCATGTATTGTTTTTTTGGAACCTCCAGACATGTATCCATAGGTCCATTCGCTGTTATTAGCCTAATGATT
GGTGGTGTGGCTGTTCGATTAGTACCAGATGATATAGTTATTCCAGGAGGGGTAAATGCAACCAATGGTACG
GAAGCAAGAGATGCCTTGAGAGTGAAAGTCGCCATGTCCGTGACCTTACTTTCAGGAATCATCCAGTTTTGC
CTAGGTGTCTGTAGGTTTGGATTTGTGGCCATATATCTTACGGAGCCCCTGGTCCGTGGGTTTACCACCGCG
GCTGCTGTGCACGTCTTCACCTCCATGTTAAAATACCTGTTTGGAGTTAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTC
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAGGAGAAATTACCGGCA
CCTATTCCTTTAGAGTTCTTTGCGGTGGTGATGGGAACTGGCATTTCAGCTGGGTTTAACTTGCAAGAATCG
TACAATGTGGATGTCGTCGGGACACTTCCTCTGGGGCTACTACCTCCAGCCAACCCGGACACCAGCCTCTTC
CACCTCGTGTACGTGGATGCCATCGCCATAGCCATTGTTGGATTTTCAGTGACCATCTCAATGGCCAAGACA
TTGGCAAATAAACATGGCTACCAGGTAGATGGCAATCAG---------GAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCACTCTTCCAGACTTTCTCAATTTCATGCTCCTTATCTCGAAGCCTTGTTCAAGAGGGG
ACTGGAGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCACTAATGATTCTGCTGGTCATATTAGCCACCGGG
TTCCTCTTCGAATCATTGCCCCAGGCTGTGCTGTCGGCCATTGTGATTGTCAACCTGAAAGGAATGTTCATG
CAATTCTCAGATCTCCCCTTTTTCTGGAGAACGAGCAAAATAGAACTGACCATTTGGCTGACCACTTTTGTT
TCCTCCTTGTTCCTGGGATTGGACTATGGTTTGATCACAGCTGTGATCATCGCTCTGCTGACTGTGATTTAC
AGAACCCAGAGTCCCAGCTACAAAGTGCTTGGACAGCTTCCTGACACTGACGTGTATATTGATATAGATGCA
TATGAGGAGGTAAAAGAAATTCCTGGAATAAAAATATTCCAAATCAATGCCCCAATTTATTATGCAAATAGC
GACTTATATAGCAATGCTTTAAAAAGAAAGACTGGAGTGAACCCAGCGCTCATAATGGGAGCAAGAAGAAAG
GCCATGAAGAAGTATGCTAAGGAAGTTGGAAATGCAAATATGGCCAATGCAACTGCTGTCAAAGTG------
GATGCAGAAGTCGATGGAGAAGATGCCACGAAGCCTGAAGAAGAGGATGACGAAGTAAAATACCCCCCAATA
GTCATCAAGAGCACATTTCCTGAAGAAATGCAAAGATTTATGCCCCCAGGGGATAACATCCACACCATCATT
CTGGATTTTACACAAGTCAATTTTATTGACTCTGTTGGTGTAAAAACTCTGGCCGGGATTGTAAAAGAATAT
GGAGATGTCGGTATTTATGTGTATTTAGCAGGATGCAGCGCACAAGTTGTGAATGACCTCACTCAAAATCGA
TTCTTTGAAAATCCTGCCTTGAAGGAGCTGCTGTTCTACAGCATTCATGATGCAGTTTTAGGCAGCCAGCTT
CGGGAGGCGCTTGCCGAGCAAGAAGCCACCGCTGCCCCTCCGCGGGAGGACTCAGAACCCAACGCCACTCCA
GAAGCT
>Panthera_pardus/1-2223
ATGGATCATGCTGAAGAAAATGAAATCCTTGCAGCAAGCCAGAGGTACTATGTGGAAAGGCCTATCTTCAGC
CATCTGGTCCTCCAGGAAAGACTTCACAAGAAGGACAAGATTTCAGATTCCATCGGGGATAAGCTGAAACAG
GCATTCACATGTACTCCTAAGAAGATACGAAATATCATTTATATGTTCCTGCCCATAACTAAGTGGTTGCCC
GCGTACAAATTCAAAGAGTATGTGTTGGGTGACTTGGTCTCAGGCATAAGCACAGGGGTACTTCAGCTTCCT
CAAGGGTTAGCCTTTGCAATGCTGGCTGCTGTGCCTCCGGTGTTTGGCCTGTACTCTTCATTTTATCCTGTT
ATAATGTATTGTTTTTTTGGAACCTCCAGACATGTATCCATAGGTCCGTTCGCTGTTATTAGCCTGATGATT
GGTGGTGTGGCTGTTCGATTAGTACCAGATGATATAGTTATTCCAGGAGGGGTAAATGCAACCAATGGTACG
GAAGCAAGAGATGCCTTGAGAGTGAAAGTCGCCATGTCCGTGACCTTACTTTCAGGAATCATCCAGTTTTGC
CTAGGTGTCTGTAGGTTTGGATTTGTGGCCATATATCTTACGGAGCCCCTGGTCCGTGGGTTTACCACCGCG
GCTGCTGTGCACGTCTTCACCTCCATGTTAAAATACCTGTTTGGAGTTAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTC
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAGGAGAAATTACCGGCA
CCTATTCCTTTAGAGTTCTTTGCGGTGGTGATGGGAACTGGCATTTCAGCTGGGTTTAACTTGCAAGAATCG
TACAATGTGGATGTCGTCGGGACACTTCCTCTGGGGCTACTACCTCCAGCCAACCCGGACACCAGCCTCTTC
CACCTCGTGTACGTGGATGCCATCGCCATAGCCATTGTTGGATTTTCAGTGACCATCTCAATGGCCAAGACC
TTGGCAAATAAACATGGCTACCAGGTGGATGGCAATCAG---------GAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCACTCTTCCAGACTTTCTCAATTTCATGCTCCTTATCTCGAAGCCTTGTTCAAGAGGGG
ACTGGAGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCACTAATGATTCTGCTGGTCATATTAGCCACCGGG
TTCCTCTTCGAATCATTGCCCCAGGCTGTGCTGTCGGCCATTGTGATTGTCAACCTGAAAGGAATGTTCATG
CAATTCTCAGATCTCCCCTTTTTCTGGAGAACGAGCAAAATAGAACTGACCATTTGGCTGACCACTTTTGTT
TCCTCCTTGTTCCTGGGATTGGACTATGGTTTGATTACAGCTGTGATCATCGCTCTGCTGACTGTGATTTAC
AGAACCCAGAGTCCCAGCTACAAAGTGCTTGGACAGCTTCCTGACACTGACGTGTATATTGATATAGATGCA
TATGAGGAGGTGAAAGAAATTCCCGGAATAAAAATATTCCAAATCAATGCCCCAATTTATTATGCAAATAGC
GACTTATATAGCAATGCTTTAAAAAGAAAGACTGGAGTGAACCCAGCGCTCATAATGGGAGCAAGAAGAAAG
GCCATGAAGAAGTATGCTAAGGAAGTTGGAAATGCAAATATGACCAATGCAACTGCAGTCAAAGTG------
GATGCAGAAGTAGATGGAGAAGATGCCACGAAGCCTGAAGAAGAGGATGACGAAGTAAAATACCCCCCAATA
GTCATCAAGAGCACATTTCCTGAAGAAATGCAAAGATTTATGCCCCCAGGAGATAACATCCACACCATCATT
CTGGATTTTACACAAGTCAATTTTATTGACTCTGTTGGCGTAAAAACTCTGGCTGGGATTGTAAAAGAATAT
GGAGATGTCGGTATTTATGTGTATTTAGCAGGATGCAGCGCACAAGTTGTGAATGACCTCACTCAAAATCGA
TTCTTTGAAAATCCTGCCTTGAAGGAGCTGCTGTTCTACAGCATTCATGATGCAGTTTTAGGCAGCCAGCTT
CGGGAGGCGCTTGCCGAGCAAGAAGCCACCGCCGCCCCTCCGCAGGAGGACTCAGAACCCAACGCCACTCCA
GAAGCT
>Panthera_tigris_altaica/1-2223
ATGGATCATGCTGAAGAAAATGAAATCCTTGCAGCAAGCCAGAGGTACTATGTGGAAAGGCCTATCTTCAGC
CATCTGGTCCTCCAGGAAAGACTTCACAAGAAGGACAAGATTTCAGATTCCATCGGGGATAAGCTGAAACAG
GCATTCACATGTACTCCTAAGAAGATACGAAATATCATTTATATGTTCCTGCCCATAACTAAGTGGTTGCCC
GCGTACAAATTCAAAGAGTATGTGTTGGGTGACTTGGTCTCAGGCATAAGCACAGGGGTACTTCAGCTTCCT
CAAGGGTTAGCCTTTGCAATGCTGGCTGCTGTGCCTCCGGTGTTTGGCCTGTACTCTTCATTTTATCCTGTT
ATAATGTATTGTTTTTTTGGAACCTCCAGACATGTATCCATAGGTCCGTTCGCTGTTATTAGCCTGATGATT
GGTGGTGTGGCTGTTCGATTAGTACCAGATGATATAGTTATTCCAGGAGGGGTAAATGCAACCAATGGTACG
GAAGCAAGAGATGCCTTGAGAGTGAAAGTCGCCATGTCCGTGACCTTACTTTCAGGAATCATCCAGTTTTGC
CTAGGTGTCTGTAGGTTTGGATTTGTGGCCATATATCTTACGGAGCCCCTGGTCCGTGGGTTTACCACCGCG
GCTGCTGTGCACGTCTTCACCTCCATGTTAAAATACCTGTTTGGAGTTAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTC
GGGCTGATGGTTTTTGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAGGAGAAATTACCGGCA
CCTATTCCTTTAGAGTTCTTTGCGGTGGTGATGGGAACTGGCATTTCAGCTGGGTTTAACTTGCAAGAATCG
TACAATGTGGATGTCGTCGGGACACTTCCTCTGGGGCTACTACCTCCAGCCAACCCGGACACCAGCCTCTTC
CACCTCGTGTACGTGGATGCCATCGCCATAGCCATTGTTGGATTTTCAGTGACCATCTCAATGGCCAAGACC
TTGGCAAATAAACATGGCTACCAGGTGGATGGCAATCAG---------GAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCACTCTTCCAGACTTTCTCAATTTCATGCTCCTTATCTCGAAGCCTTGTTCAAGAGGGG
ACTGGAGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCACTAATGATTCTGCTGGTCATATTAGCCACCGGG
TTCCTCTTCGAATCATTGCCCCAGGCTGTGCTGTCGGCCATTGTGATTGTCAACCTGAAAGGAATGTTCATG
CAATTCTCAGATCTCCCCTTTTTCTGGAGAACGAGCAAAATAGAACTGACCATTTGGCTGACCACTTTTGTT
TCCTCCTTGTTCCTGGGATTGGACTATGGTTTGATTACAGCTGTGATCATCGCTCTGCTGACTGTGATTTAC
AGAACCCAGAGTCCCAGCTACAAAGTACTTGGACAGCTTCCTGACACTGACGTGTATATTGATATAGATGCA
TATGAGGAGGTGAAAGAAATTCCTGGAATAAAAATATTCCAAATCAATGCCCCAATTTATTATGCAAATAGC
GACTTATATAGCAATGCTTTAAAAAGAAAGACTGGAGTGAACCCAGCGCTCATAATGGGAGCAAGAAGAAAG
GCCATGAAGAAGTATGCTAAGGAAGTTGGAAATGCAAATATGGCCAATGCAACTTCTGTCAAAGTG------
GATGCAGAAGTAGATGGAGAAGATGCCACGAAGCCTGAAGAAGAGGATGACGAAGTAAAATACCCCCCAATA
GTCATCAAGAGCACATTTCCTGAAGAAATGCAAAGATTTATGCCCCCAGGGGATAACATCCACACCATCATT
CTGGATTTTACACAAGTCAATTTTATTGACTCTGTTGGCGTAAAAACTCTGGCCGGGATTGTAAAAGAATAT
GGAGATGTCGGTATTTATGTGTATTTAGCAGGATGCAGCGCACAAGTTGTGAATGACCTCACTCAAAATCGA
TTCTTTGAAAATCCTGCCTTGAAGGAGCTGCTGTTCTACAGCATTCATGATGCAGTTTTAGGCAGCCAGCTT
CGGGAGGCGCTTGCCGAGCAAGAAGCCACCGCCGCCCCTCCCCAGGAGGACTCAGAACCCAACGCCACTCCA
GAAGCT
>Balaenoptera_acutorostrata_scammoni/1-2223
ATGGATCATGCTGAAGAAAATGAAATCCTTGCAGCAGCCCAGCGGTACTATGTGGAAAGACCTATCTTTAGT
CATCTGGTCCTCCAAGAAAGACTGCACAAGAAGGACAAGATTTCGGATTCCATCGGCGATAAGCTGAAACAG
GCATTCACATGTACTCCTAAGAAAATACGAAATATCATTTACATGTTCCTCCCCATAACCAAGTGGTTGCCT
GCATACAGATTCAAGGAGTATGTGTTGGGTGACTTAGTCTCAGGCATAAGCACAGGAGTGCTGCAGCTTCCT
CAAGGTTTAGCCTTTGCAATGTTGGCAGCTGTGCCTCCGGTGTTTGGCCTGTACTCTTCATTTTACCCCGTT
ATCATGTATTGTTTTTTTGGAACCTCCAGACACATATCCATAGGTCCGTTTGCAGTTATTAGCCTGATGATA
GGCGGCGTGGCTGTTCGATTAGTACCAGATGATATGGTCATTCCAGGAGGAGTAAATGCAACCAACGGTACG
GAGGCAAGAGATGCTTTGAGAGTGAAAGTCGCCATGTCTGTGACCTTACTTTCAGGAATCATTCAGTTTTGC
CTAGGTGTCTGTAGGTTTGGATTTGTGGCCATATATCTCACGGAGCCCCTGGTCCGTGGGTTTACCACTGCG
GCAGCTGTGCATGTCTTCACCTCCATGTTAAAATACCTGTTTGGAGTTAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGTACAGTTGCTGTGTTGCAGAATGTTAAAAACCTCAACGTGTGTTCCCTAGGCGTT
GGGCTGATGGTCTTTGGTTTGCTGCTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAATTGCCAGCA
CCCATCCCTTTAGAGTTCTTTGCGGTGGTTATGGGAACTGGCATTTCAGCTGGGTTTAACCTGAATGAATCA
TACAATGTGGATGTCGTTGGGACACTTCCTCTGGGGCTGCTACCTCCGGCCAATCCGGACACCAGCCTCTTC
CACCTTGTGTACGTGGATGCCATTGCCATAGCCATCGTTGGATTTTCAGTGACCATCTCAATGGCCAAGACC
TTGGCAAATAAGCATGGCTACCAGGTTGATGGCAATCAG---------GAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCACTCTTCCAGACGTTTTCAATTTCATGCTCCTTGTCTCGAAGCCTTGTTCAGGAGGGA
ACTGGAGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCGTTAATGATTCTGCTGGTCATATTAGCCACTGGA
TTCCTCTTTGAATCATTACCCCAGGCTGTGCTGTCGGCCATTGTGATCGTCAACCTGAAAGGAATGTTTATG
CAATTCTCAGATCTCCCGTTTTTCTGGAGAACCAGCAAGATAGAGCTGACCATCTGGCTTACCACTTTTGTT
TCCTCCTTGTTCCTGGGATTGGACTATGGCTTGATTACTGCTGTGATCATCGCACTGCTGACTGTGATTTAC
AGAACACAGAGTCCGAGCTACAAAGTCCTTGGGCAGCTTCCTGACACTGATGTGTACATTGACATAGACGCG
TATGAGGAGGTGAAAGAAATTCCTGGAATAAAAATATTCCAAATAAATGCCCCAATTTATTATGCAAATAGT
GACTTATACAGCAGTGCATTAAAAAGAAAGACTGGAGTGAACCCAGCCCTCATAATGGGAGCAAGAAGAAAG
GCCATGAAGAAGTATGCTAAGGAAGTTGGAAATGCCAACATGGCCAATGCAACCATCGTCAAAGTG------
GATGCAGAAGTAGATGGAGAAGACGGCACCAAGCCTGAGGAAGAGGAGAATGAAATAAAATATCCCCCAGTA
GTCATCAAGAGCACACTTCCTGAGGAACTGCAAAGATTTATGCCCCCAGGGGATAACGTCCACACCATCATT
CTGGATTTTACGCAAGTCAATTTTATTGATTCCGTTGGTGTAAAAACTCTGGCAGGGATTGTAAAAGAATAT
GGAGATGTCGGCATTTATGTGTATTTAGCAGGATGCAGTGCACAAGTCGTGAATGACCTCAGTCGAAATCAA
TTCTTTGAAAATCCTGCCTTACTGGAGCTGCTGTTCCACAGCATTCACGACGCAGTCTTAGGCAGCCAAGTT
CGAGAGGCACTTGCCGAACAGGAGGCCACGGCTGCCCCTCCCCAGGAGGACTCTGAGCCCAACGCCACTCCG
GAGGCT
>Odobenus_rosmarus_divergens/1-2220
ATGGATCATGCTGAAGAAAATGAAATCCTCGCAGCAAGCCAGAGGTACTATGTGGAAAGGCCTATCTTTAGT
CACCCGGTCCTCCAGGAAAGACTGCACAAGAAGGACAAAATTTCAGATTCCATCGGGGATAAGCTGAAACAG
GCATTCACATGTACTCCTAAGAAGATACGAAATATCATTTATATGTTCCTGCCCATAACAAAGTGGTTACCG
GCATACAAGTTCAAAGAGTATGTGTTGGGTGACTTGGTCTCAGGTATAAGCACAGGGGTGCTTCAGCTTCCT
CAAGGGTTAGCCTTTGCAATGCTGGCTGCCGTACCTCCAGTGTTTGGCCTGTACTCTTCATTTTACCCTGTT
ATCATGTATTGTTTTTTTGGAACCTCCAGACACATATCCATAGGTCCATTTGCTGTGATTAGCCTGATGATT
GGCGGTGTGGCTGTTCGATTAGTACCAGATGATATAGTCATTCCAGGAGGAGTGAATGCAACCAACGGGACA
GAAGCAAGAGATGCCTTGAGGGTGAAAGTTGCCATGTCTGTGACCTTACTTTCAGGAATCATCCAGTTTTGC
CTAGGTGTCTGTAGGTTTGGATTTGTGGCCATATATCTCACAGAGCCCCTGGTCCGGGGGTTTACCACCGCG
GCAGCTGTGCACGTCTTCACCTCCATGTTGAAATACCTGTTTGGAGTGAAAACAAAGCGGTACAGTGGGATC
TTTTCAGTGGTGTATAGCACAGTTGCTGTGTTGCAGAATGTTAGAAACCTCAACGTGTGTTCTCTAGGCGTC
GGGCTGATGGTTTTCGGTTTGCTGTTGGGTGGCAAGGAGTTTAATGAGAGATTTAAAGAGAAATTACCTGCA
CCCATTCCTTTAGAGTTCTTTGCGGTGGTGATGGGGACTGGCATTTCAGCTGGGTTTAACCTGGAAGAATCC
TACAATGTGGATGTCGTTGGGACACTTCCTCTGGGGCTACTGCCTCCAGCCAACCCGGACACCAGCCTCTTC
CACCTTGTGTACGTGGATGCCATCGCCATAGCCATTGTTGGATTTTCAGTGACCATCTCAATGGCCAAGACC
TTGGCAAATAAACATGGCTACCAGGTTGATGGCAATCAG---------GAGCTCATTGCCCTGGGACTGTGC
AATTCCATTGGCTCACTCTTCCAGACTTTCTCCATTTCATGCTCCTTGTCTCGAAGCCTTGTTCAGGAGGGA
ACTGGAGGGAAGACACAGCTTGCAGGTTGTTTGGCCTCGCTAATGATTCTGCTGGTCATATTAGCCACCGGA
TTCCTCTTTGAATCATTACCCCAGGCTGTGCTGTCAGCCATTGTGATTGTCAACCTGAAAGGAATGTTTATG
CAATTCTCAGATCTCCCCTTTTTCTGGAGAACAAGCAAAATAGAACTGACCATCTGGCTTACCACTTTTGTT
TCCTCCCTGTTCCTGGGATTGGACTATGGTTTGATTACAGCTGTGATCATTGCTCTGCTAACTGTGATTTAC
AGAACACAGAGTCCCAGCTACAAAGTCCTTGGACAGCTTCCCGACACAGATGTGTATATCGATATAGATGCA
TATGAAGAGGTGAAAGAAATTCCTGGAATAAAAATATTCCAAATAAATGCCCCAATTTATTATGCAAATAGC
GACTTGTATAGCAGTGCTTTGAAAAGAAAGACTGGAGTGAACCCAGCATTCATAATGGGAGCAAGAAGAAAG
GCCATGAAGAAGTATGCTAAGGAAGTTGGAAATGCAAATGTGGCCAACGCAACCGTTGTCAAAGTG------
GATGCAGAAGTAGATGGAGAAGATGCCACGAAGCCTGAA---GATGATGATGAAGTAAAATATCCCCCGATA
GTCATCAAGAGCACAGTCCCTGAGGAACTGCAAAGATTTATGCCCCCGGGGGATAACATCCACACTGTCATT
CTGGACTTTACGCAAGTCAACTTTATTGACTCTGTTGGCGTGAAAAGCCTGGCTGGGATTGTAAAAGAATAT
GGAGATGTCGGTATTTATGTGTATTTAGCAGGATGCAGCGCACAAGTTGTAAACGACCTCACTCAAAATCGA
TTTTTTGAAAATCCTGCCTTGAAGGAGCTGCTGTTCCACAGCATCCACGATGCAGTGTTAGGCAGCCAGCTT
CGGGAAGCGCTTGTTGGGCAAGACGCCTCGGCTCTCCCTCCCCTGGAGGACTCAGAGCCCAATGCCACTCCA
GAAGCA

Memory issues with SMC at gene-level datasets :( 

However:

Outlook for treeppl

  • More efficient memory management under SMC
  • Improved "phylogenetic" MCMC schemes
  • Userland improvements

Applications of ppl's Beyond Biology

PPL's in the ai space

Tesla neural AI vs horse-drawn carriage

The problem with neural AI's is that not only are they confused, but when they are confused they don't know it.

~ after V. Mansingkha

  • NN's lack a symbolic representation of the world
  • NN's lack a robust way of dealing with uncertainty
  • Can be overcome by PPL-based system

PPL APPLICATIONS  for 3d scene perception

📰 Gothoskar, Nishad, et al. "Bayes3D: fast learning and inference in structured generative models of 3D objects and scenes." arXiv preprint arXiv:2312.08715 (2023).

CAUSALITY

📰 Tavares, Zenna, et al. "A language for counterfactual generative models." International conference on machine learning. PMLR, 2021.

OmegaC - a PPL for counterfactual inference.

 

Julia implementation: https://github.com/zenna/Omega.jl

Haskell implementation: https: //github.com/jkoppel/omega-calculus

let drivermodel = λ car, ped, obs .
if cansee(car, ped, obs) -- if ped is visible
then -9 -- decelerate
else 0, -- else maintain
CarV = ~ normal(12, 4),
CarP = ~ normal(30, 5),
PedV = ~ normal(3, 1),
PedP = ~ normal(1, 2),
InitScene = (CarV, CarP, PedV, PedP, obs),
Traj = simulate(InitScene, drivermodel),
Images = map(render, Traj),
  -- Would the crash have occurred given the trajectory that would have resulted from the CarV being set to 14?
E = (Images[t] == data) and crashed(Traj)
in (Traj | do(CarV → 14)) | E

-- alternatively, we moved the obstacle 3 units away
-- in (Traj | do(obs → obs - 3)) | E

Even at the speed limit, the car would have crashed into the pedestrian, but moving the obstacle to improve vision would have avoided the crash.

USING PPLs for data processing

📰 Winn, John, et al. "Enterprise Alexandria: Online high-precision enterprise knowledge base construction with typed entities." 3rd Conference on Automated Knowledge Base Construction. 2021.

📰 Lew, Alexander, et al. "PClean: Bayesian data cleaning at scale with domain-specific probabilistic programming." International conference on artificial intelligence and statistics. PMLR, 2021.

explainable aI

?

summary

  • PPLs are more than just a useful tool for science but statistics but could potentially be a corner-stone in future AI research

how will democratization happen then?

  1. PPLs make Bayesian statistics accessible to practioners
  2. No need to implement a custom-schema yourself
  3. DSL PPLs have a syntax that is intuitive and understandable for domain experts in the field ➡️➡️ more models by component reuse

David Broman

Daniel Lundén

Emma Granqvist

Fredrik Ronquist

Gizem Çaylak

Viktor Palmkvist

Ignacio Quintero

Jan Kudlicka

Jérémy Andréoletti

Mariana Braga

Hélène Morlon

and many others...

thank you

Funded by the EU Horizon 2020 Marie Skłodowska-Curie grant agreement PhyPPL No. 898120,
and by the Swedish Foundation for Strategic Research, as well as Vetenskapsrådet (VR).

Download and installation: https://github.com/treeppl/treeppl

📰 Senderov et al. "TreePPL: A Universal Probabilistic Programming Language for Phylogenetics." 2023 doi: https://doi.org/10.1101/2023.10.10.561673